2011 Fiscal Year Final Research Report
Identification and characterization of novel omega-3 polyunsaturated fatty acid-derived mediator with anti-inflammatory property
| Project/Area Number |
21370051
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ARITA Makoto 東京大学, 大学院・薬学系研究科, 准教授 (80292952)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ホルモンと生理活性物質 |
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| Research Abstract |
In this study, we identified a novel omega-3 polyunsaturated fatty acid-derived anti-inflammatory mediator 17, 18-diHEPE, termed resolvin E3(RvE3). The chemical structure of RvE3 was determined by LC-MS/MS-based lipidomics, stereoselective organic synthesis, and high-resolution NMR. Unlike previously identified RvE1 and RvE2, both of which are biosynthesized by neutrophils via 5-LOX pathway, RvE3 was biosynthesized by eosinophils via 12/15-LOX pathway. RvE3 at nanogram dosages displayed a potent anti-inflammatory action in vivo by limiting neutrophil infiltration in zymosan-induced peritonitis. These findings propose a novel metabolic cascade for the beneficial actions of omega-3 fatty acid in controlling inflammation and related diseases
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[Journal Article] Identification and structure determination of a novel anti-inflammatory mediator resolvin E3 : 17, 18-dihydroxy-eicosapentaenoic acid.2012
Author(s)
Isobe Y, * Arita M, Matsueda S, Iwamoto R, Fujihara T, Nakanishi H, Taguchi R, Masuda K, Sasaki K, Urabe D, Inoue M, Arai H
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Journal Title
J. Biol. Chem
Volume: 287
Pages: 10525-10534
DOI
Peer Reviewed
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[Journal Article] The anti-inflammatory and pro-resolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury2010
Author(s)
Seki H, Fukunaga K, Arita M, Arai H, Nakanishi H, Taguchi R, Miyasho T, Takamiya R, Asano K, Ishizaka A, Takeda J, Levy BD
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Journal Title
J. Immunol
Volume: 184
Pages: 836-843
DOI
Peer Reviewed
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[Journal Article] Lipoxin A4 reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of NF-kB activation2010
Author(s)
Kure I, Nishiumi S, Nishitani Y, Tanoue T, Ishida T, Mizuno M, Fujita T, Kusumi H, Arita M, Azuma T, Yoshida M
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Journal Title
J J Pharmacol Exp Ther
Volume: 332
Pages: 541-548
DOI
Peer Reviewed
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[Journal Article] Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis2010
Author(s)
Ishida T, Yoshida M, Arita M, Nishitani Y, Nishiumi S, Masuda A, Mizuno S, Takagawa T, Morita Y, Kusumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T
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Journal Title
Inflamm. Bowel Dis
Volume: 16
Pages: 87-95
DOI
Peer Reviewed
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