2011 Fiscal Year Final Research Report
Role of neural specific carbohydrates in neural plasticity
| Project/Area Number |
21370053
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
OKA Shogo 京都大学, 医学研究科, 教授 (60233300)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASAKI Nana 国立医薬品食品衛生研究所, 生物薬品部, 部長 (20186167)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 糖鎖生物学 / 神経可塑性 |
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| Research Abstract |
HNK-1 carbohydrate has important roles in higher brain functions such as learning and memory. However, it remains unclear how HNK-1 regulates these functions. In this study, using the GlcAT-P-deficient mice, we demonstrated that loss of HNK-1 carbohydrate resulted in increased filopodia-like immature spines both in early postnatal mice and in cultured hippocampal neurons. We also identified a novel HNK-1 carbohydrate carrier molecule as AMPA type glutamate receptor subunit GluR2.
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