2011 Fiscal Year Final Research Report
Molecular mechanism of the desiccation tolerance induced by trehalose and LEA proteins in anhydrobiotic organisms
| Project/Area Number |
21370068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
SAKURAI Minoru 東京工業大学, バイオ研究基盤支援総合センター, 教授 (50162342)
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| Co-Investigator(Renkei-kenkyūsha) |
KIKAWADA Takahiro 独立行政法人農業生物資源研究所, 乾燥耐性研究ユニット, 主任研究員 (60414900)
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| Project Period (FY) |
2009 – 2011
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| Keywords | タンパク質 / 核酸の構造 / 動態 / 機能 |
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| Research Abstract |
We have revealed some of the molecular mechanisms responsible for the desiccation tolerance of anhydrobiotic organisms such as Polypedilum vanderplanki. Fisrt is the structuralization of LEA proteins in the dry state and their vitrification with trehalose(steel-reinforced concrete model). Second is the ion-scavenger effect of LEA proteins and their anti-aggregation effect against on proteins during desiccation. Furthermore, we have obtained the invaluable information about the substrate transport mechanism of trehalose transporter.
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