2012 Fiscal Year Final Research Report
Study of molecular coordination between nuclear and mitochondrial replications.
| Project/Area Number |
21370076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2012
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| Keywords | オルガネラ / チェックポイント制御 / 複製 / ミトコンドリア / ATR |
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| Research Abstract |
ATR is highly conserved in all eukaryotes and functions as a cell-cycle nuclear checkpoint kinase. In mammals, ATR hypomorphic mutation causes a complex disease known as Seckel syndrome. However, molecular mechanisms that cause a wide variety of symptoms including accelerated aging have remained unclear. We here found that in the nematode Caenorhabditis elegans, a deletion mutant of ATR atl-1 achieved longevity. Transcription levels of certain superoxide dismutase genes significantly increased in the mutant. In addition, mammalian ATR over-expression induced autophagic cell death.
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Research Products
(19 results)
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[Journal Article] Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans2012
Author(s)
Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk NJ, Ishioka N, Honda S
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Journal Title
Sci Rep
Volume: 2
Pages: 487
DOI
Peer Reviewed
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[Journal Article] The effectiveness of RNAi in Caenorhabditis elegans is maintained during spaceflight2011
Author(s)
Etheridge T, Nemoto K, Hashizume T, Mori C, Sugimoto T, Suzuki H, Fukui K, Yamazaki T, Higashibata A, Szewczyk NJ, Higashitani A
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Journal Title
PLoS One
Volume: 6(6)
Pages: e20459
DOI
Peer Reviewed
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