2011 Fiscal Year Final Research Report
Molecular mechanism of cell polarity establishment and cell-face determination by RNA localization and local translation
| Project/Area Number |
21370077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
IRIE Kenji 筑波大学, 医学医療系, 教授 (90232628)
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| Co-Investigator(Renkei-kenkyūsha) |
NAIKI Takahiro 筑波大学, 医学医療系, 助教 (70420081)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞極性 / 細胞運命 / mRNA / RNA結合タンパク質 / Stau1 / 出芽酵母 / 筋分化 / 細胞壁合成 |
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| Research Abstract |
Post-transcriptional regulation of gene expression has a significant role in various cellular processes such as cell growth, cell differentiation, adaptation to stress, and cell death. In our study, we are focusing on understanding the molecular mechanism and the physiological function of the post-transcriptional regulation by RNA-binding proteins using yeast and mammalian cells. We have revealed that RNA-binding protein Khd1 and cytoplasmic deadenylase Ccr4 modulate a signal from Rho1 in the yeast cell wall integrity pathway by regulating the expression of RhoGEF and RhoGAP. We have also revealed that RNA-binding protein Stau1 coordinates myogenesis through the regulation of Dvl2 mRNA encoding a central mediator of Wnt pathway.
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