2012 Fiscal Year Final Research Report
Mechanisms of mRNA quality control by eRF3 family G proteins
| Project/Area Number |
21370080
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Nagoya City University |
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Principal Investigator |
HOSHINO Shinichi 名古屋市立大学, 大学院・薬学研究科, 教授 (40219168)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHODA Nao 名古屋市立大学, 大学院・薬学研究科, 講師 (40438198)
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| Project Period (FY) |
2009 – 2012
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| Keywords | mRNA品質管理 / eRF3 / 翻訳終結 / mRNA分解 / Gタンパク質 |
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| Research Abstract |
We have previously demonstrated that mRNA decay is initiated in couple with translation termination, where eukaryotic releasing factor eRF3 plays central roles. Here we showed that mRNA quality control mechanism eliminating aberrant transcripts lacking stop codon exists in mammalian cells, where another eRF3 family G protein Hbs1 and exosome complex play essential roles.
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[Journal Article] Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay.2012
Author(s)
Osawa, M., Hosoda, N., Nakanishi, T., Uchida, N., Kimura, T., Imai, S., Machiyama, A., Katada, T., Hoshino, S., Shimada, I.
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Journal Title
RNA
Volume: 18
Pages: 1957-1967
Peer Reviewed
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[Journal Article] Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.2011
Author(s)
Hosoda, N., Funakoshi, Y., Hirasawa, M., Yamagishi, R., Asano, Y., Miyagawa, R., Ogami, K., Tsujimoto, M., Hoshino, S.
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Journal Title
EMBO J
Volume: 30
Pages: 1311-1323
Peer Reviewed
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[Journal Article] Quantitative characterization of TOB interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation.2010
Author(s)
Ruan,L., Osawa, M., Hosoda, N., Imai, S., Machiyama, A., Katada, T., Hoshino, S. and Shimada I.
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Journal Title
J Biol Chem
Volume: 285
Pages: 27624-27631
Peer Reviewed
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