2012 Fiscal Year Final Research Report
Studies on cell functions regulated by changes in membrane phospholipid asymmetry
| Project/Area Number |
21370085
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
TANAKA Kazuma 北海道大学, 遺伝子病制御研究所, 教授 (60188290)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 生体膜 / 脂質の非対称性 / フリッパーゼ / 細胞内小胞輸送 / 酵母 |
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| Research Abstract |
Lipids are essential components of cell membranes. Abnormal distribution or transport of lipids is related to diseases, but much remains to be learned. In this study, we focus on phospholipid flippases, which transport phospholipids to the cytoplasmic leaflet of membranes, and have shown that flippases are involved in protein sorting and vesicle formation. We have also identified new genes that regulate phospholipid asymmetry of intracellular membranes.
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Research Products
(25 results)
