2011 Fiscal Year Final Research Report
Molecular and functional analysis of Notch signaling in organogenesis
| Project/Area Number |
21370090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Chiba University (2011)
Nagoya University (2009-2010) |
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Principal Investigator |
MOTOYUKI Itoh 千葉大学, 大学院・薬学研究院, 教授 (20377906)
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| Co-Investigator(Renkei-kenkyūsha) |
KOICHI Kawakami 国立遺伝学研究所, 個体遺伝研究系, 教授 (70195048)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 器官形成 / Notch zebrafish |
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| Research Abstract |
Notch signaling is an evolutionary conserved pathway that plays an important role in the development of various organs. In this study, physiological functions of Notch ligands and the mechanism by which Notch activity is regulated were analyzed using zebrafish. We found a previously unrecognized mechanism regulating the patterning and structural roles of the notochord by Mib-Jag1-Notch signaling. Furthermore, using a biochemical screen, we identified Notch as a new substrate of NLK. NLK-phosphorylated Notch1 intercellular domain is impaired in its ability to form a transcriptionally active ternary complex.
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[Journal Article] Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions2010
Author(s)
Yamamoto M, Morita R, Mizoguchi T, Matsuo H, Isoda M, Ishitani T, Chitnis AB, Matsumoto K, Crump JG, Hozumi K, Yonemura S, Kawakami K, Itoh M.
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Journal Title
Development
Volume: 137
Pages: 2527-37
DOI
Peer Reviewed
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