Gene networks underlying development of the Drosophila central nervous system

2011 Fiscal Year Final Research Report

• Project/Area Number: 21370096
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: The University of Tokyo
• Principal Investigator: TABATA Tetsuya 東京大学, 分子細胞生物学研究所, 教授 (10183865)
• Project Period (FY): 2009 – 2011
• Keywords: ショウジョウバエ / 視覚中枢 / 嗅覚中枢 / キノコ体 / EGF / Notch / PCP / アクチン

Research Abstract

The molecular mechanisms underlying development of Drosophila lamina and medulla optic ganglia have been studied. We have identified(1) cell surface molecules that are required for recognition between lamina precursor cells and retinal axons,(2) coordinated sequential action of the EGFR and Notch signaling pathways that induce medulla neuroblasts formation in a precisely ordered manner. We have also identified genes involved in planer cell polarity and actin remodeling as important players that regulate axon elongation and guidance of the mushroom body, the center of the olfactory memory formation.

Research Products

• [Journal Article] Concentric zones, cell migration and neuronal circuits in the Drosophila visual center (2011)
  • Author(s): Hasegawa*, E., Kitada*, Y., Kaido, M., Takayama, R., Awasaki, T., Tabata, T. and Sate, M.
  • Journal Title: Development Volume: 138 Pages: 983-993
  • Peer Reviewed
• [Journal Article] The Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe (2011)
  • Author(s): Kawamori, H., Tai, M., Sato, M., Yasugi, T., Tabata, T.
  • Journal Title: Growth Diff Volume: 53 Pages: 653-667
  • Peer Reviewed
• [Journal Article] The Wnts/Planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron (2011)
  • Author(s): Shimizu, K., Sate, M. and Tabata, T.
  • Journal Title: J. Neuroscience Volume: 31 Pages: 4944-4954
  • Peer Reviewed
• [Journal Article] Recognition of pre-and postsynaptic neurons via nephrin/NEPHl homologs is a basis for the formation of the Drosophila retinotopic map (2010)
  • Author(s): Sugie, A., Umetsu, D., Yasugi, T., Fischbach, K.-F. and Tabata. T.
  • Journal Title: Development Volume: 137 Pages: 3303-3313
  • Peer Reviewed
• [Journal Article] Coordinated sequential action of EGFR and Notch signaling pathways regulates pro neural wave progression in the Drosophila optic lobe (2010)
  • Author(s): Yasugi, T., Sugie, A., Umetsu, D. and Tabata, T.
  • Journal Title: Development Volume: 137 Pages: 3193-3203
  • Peer Reviewed
• [Presentation] Mechanisms underlying Drosophila memory formation (2010)
  • Author(s): Tabata, T., Murakami, S.
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 20101207-10
• [Presentation] Cellular and molecular mechanisms underlying neural formation in Drosophila visual system development (2010)
  • Author(s): Tabata, T.
  • Organizer: International Symposium on Drosophila Bio-Resource :-Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: Kyoto
  • Year and Date: 20100317-18
• [Presentation] Roles of Wnt Signal in Development of Drosophila Mushroom Body (2010)
  • Author(s): Shimizu, K., Sate, M. and Tabata, T.
  • Organizer: International Symposium on Drosophila Bio-Resource :-Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: Kyoto
  • Year and Date: 20100317-18
• [Presentation] Sickle, a Neuron navigator homolog, is required for the axonal development of Drosophila mushroom body neurons (2010)
  • Author(s): Abe, T., Maeyama, Y., Yasugi, T., Murakami, S. and Tabata, T.
  • Organizer: International Symposium on Drosophila Bio-Resource :-Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: Kyoto
  • Year and Date: 20100317-18
• [Presentation] RNA interference screening for genes involved in the development of Drosophila mushroom body (2010)
  • Author(s): Nitta, Y., Shimizu, K., Ohtsubo, M. and Tabata, T.
  • Organizer: International Symposium on Drosophila Bio-Resource :-Pioneering life science research with Drosophila Genetic Resources
  • Place of Presentation: Kyoto
  • Year and Date: 20100317-18
• [Presentation] EGFR and Notch Signaling Regulates the Progression of the Proneural Wave in the Drosophila Optic Lobe Development (2009)
  • Author(s): Yasugi, T., Umetsu, D. and Tabata, T.
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-12
• [Presentation] Nephl/Nephrin homolog proteins play a role in the specific interaction between pie-and post-synaptic neurons during development of Drosophila visual system (2009)
  • Author(s): Sugie, A., Fischbach, K.-F. and Tabata, T.
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-12
• [Presentation] Spatio-temporal regulation of DER and Notch signaling pathways organizes the pro neural wave progression in medulla neuroblast development (2009)
  • Author(s): Tabata, T.
  • Organizer: Neurobiology of Drosophila
  • Place of Presentation: Cold Spring Harbor Laboratory, U. S. A
  • Year and Date: 20090929-1003
• [Presentation] Role for the EGFR and JAK/STAT Signaling Pathway in the Drosophila Optic Lobe Development (2009)
  • Author(s): Yasugi, T., Umetsu, D., Murakami, S., Sate, M., and Tabata, T.
  • Organizer: 16th International Society of Developmental Biologists Congress 2009
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 20090906-10
• [Presentation] Identification of cell surface moleculesunderlying the specific interaction between pre-and post-synaptic neurons during development of Drosophila visual system (2009)
  • Author(s): Sugie, A., Fischbach, K.-F. and Tabata, T.
  • Organizer: ショウジョウバエ研究会第9回研究会
  • Place of Presentation: 静岡
  • Year and Date: 20090706-08
• [Presentation] Atypical protocadherin Fat contributes to the neurogenesis of medulla neurons in the Drosophila Opitc Lobe (2009)
  • Author(s): Kawamori, H., Tat, M., Sate, M. and Tabata, T.
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 20090602-04
• [Presentation] Cellular and molecular mechanisms underlying neural circuit formation in Drosophila visual system development (2009)
  • Author(s): Tabata. T., Yasugi, T., Sugie, A., Umetsu, D. and Fischbach, K.-F.
  • Organizer: Neural development, 42^<nd> Annual meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: Niigata
  • Year and Date: 20090528-31