2013 Fiscal Year Final Research Report
Environmental, Evolutionary Developmental Study on Changes in Gcm genes and Regulating Organs for Blood Calcium Concentration.
| Project/Area Number |
21370098
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
OKABE Masataka 東京慈恵会医科大学, 医学部, 教授 (10300716)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Saburo 東京慈恵会医科大学, 医学部, 准教授 (10186934)
MIYAKE Tsutomu 慶應義塾大学, 理工学研究科(矢上), 特任教授 (20529763)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | 脊椎動物 / 進化 / 発生 / Gcm / カルシウム |
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| Research Abstract |
During their evolution, vertebrate animals had invaded the land from water. Blood calcium needs a constant concentration to maintain normal life activities. However, a number of organs do exist for calcium regulation among vertebrate animals, depending on calcium concentration and/or its distribution in a given environment. Using mice, zebrafish and Polypterus, one of living species representing common ancestors of ray-finned fishes (actinopterygians), we have investigated evolutionary effects of changes in a number of Gcm genes and their regulatory pathways on development and function of each organ. We have carried out a construction of conditional knockout mice, enhancer analyses of Gcm genes involved in the formation of zebrafish ionocytes, developmental analyses of external gills in Polypterus and comparative genomics of Gcm genomes.
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Research Products
(9 results)
