2013 Fiscal Year Final Research Report
Molacular evolutionary background of the innovations of deuterostome morphologo
| Project/Area Number |
21370105
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
WADA Hiroshi 筑波大学, 生命環境系, 教授 (60303806)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | 後口動物 / 神経堤細胞 / 脊索 / 顎 / ギボシムシ / プルテウス幼生 / ヤツメウナギ / 咽頭弓 |
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| Research Abstract |
We investigated how the morphological features of deuterostomes were acquired, especially from the aspect of molecular evolution. We found that neural crest evolution required acquisition of a novel domain of FoxD3. In addition, we found that co-option of Alx1 and vegf signaling also contributed the evolution of pluteus larval morphology. We also succeeded to get evidence showing that lamprey mandibular arch contain two distinct cell populations, that may correspond to the upper and lower jaw. Based on this finding, we propose a new evolutionary scheme of vertebrate jaw evolution. These results indicate that novel morphology of deuterostomes were acquired through a variety of molecular evoltuion, such as acquisitions of new domain, co-option of transcription factors and heterotopic shift of signaling system.
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