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2011 Fiscal Year Final Research Report

Analyses of genome diversity in the Ryukyu islanders. to reveal their phylogeny, morphology and adaptation.

Research Project

  • PDF
Project/Area Number 21370108
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical anthropology
Research InstitutionKitasato University (2010-2011)
The University of Tokyo (2009)

Principal Investigator

OOTA Hiroki  北里大学, 医学部, 准教授 (40401228)

Co-Investigator(Kenkyū-buntansha) KIMURA Ryosuke  琉球大学, 亜熱帯島嶼科学超域研究推進機構, 特命准教授 (00453712)
Co-Investigator(Renkei-kenkyūsha) ISHIDA Hajime  琉球大学, 医学部, 教授 (70145225)
HANIHARA Tsunehiko  北里大学, 医学部, 教授 (00180919)
KAWAMURA Shoji  東京大学, 新領域創成科学研究科, 教授 (40282727)
Research Collaborator MATSUKUSA Hirotaka  東京大学, 修士
KOGANEBUCHI Kae  東京大学, 修士
NAKAGOME Shigeki  統計数理学研究所, JSPS特別研究員
KATSUMURA Takafumi  東京大学, 非常勤研究員
Project Period (FY) 2009 – 2011
Keywords琉球諸島 / 日本人の起源 / 炎症性腸疾患 / アルコール代謝 / シャベル型切歯
Research Abstract

This study revealed the followings :(i) The Ryukyu islanders were genetically closer to Honshu Japanese than Taiwan aborigine, and(ii) showed a strong relation with Hokkaido Ainu.(iii) Shovel shape of upper incisors, a common characteristic in East Asians, showed an association with a variant in EDAR gene.(iv) The mtDNA tree of the Japanese medaka showed the northern Kyushu origin that might be related to the expansion of wet rice cultivation.(v) The pattern of SNP frequencies of the genes related to alcohol metabolism was consistent with the dual structure model.

  • Research Products

    (51 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (35 results) Book (5 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A population genetic study on the relationship between medaka fish and wet-rice-cultivation spreads over the Japanese archipelago2012

    • Author(s)
      T. Katsumura, S. Oda, K. Tsukamoto, Y. Sekiya, T. Yamashita, M. Aso, M. Hata, M. Nonaka, S. Mano, H. Ishida, H. Mitani, S. Kawamura, H. Oota
    • Journal Title

      Anthropological Science

      Volume: 120(1) Pages: 81-89

    • DOI

      DOI:10.1537/ase.110525

    • Peer Reviewed
  • [Journal Article] A Genetic Analysis of the Sakishima Islanders Reveals No Relationship with Taiwan Aborigines but Shared Ancestry with Ainu and Main-island Japanese2010

    • Author(s)
      H. Matsukusa, H. Oota*, K. Haneji, T. Toma, S. Kawamura, H. Ishida
    • Journal Title

      American Journal of Physical Anthropology

      Volume: 142 Pages: 211-23

    • Peer Reviewed
  • [Journal Article] Population-specific susceptibility to Crohn's disease and ulcerative colitis ; dominant and recessive relative risks in the Japanese population2010

    • Author(s)
      S. Nakagome, Y. Takeyama, S. Mano, S. Sakisaka, T. Matsui, S. Kawamura, H. Oota
    • Journal Title

      Annals of Human Genetics

      Volume: 74 Pages: 126-36

    • Peer Reviewed
  • [Journal Article] A common variation in EDAR is a genetic determinant of shovel-shaped incisors2009

    • Author(s)
      R. Kimura, T. Yamaguchi, M. Takeda, O. Kondo, T. Toma, K. Haneji, T. Hanihara, H. Matsukusa, S. Kawamura, K. Maki, M. Osawa, H. Ishida, H. Oota
    • Journal Title

      American Journal of Human Genetics

      Volume: 85 Pages: 528-535

    • Peer Reviewed
  • [Journal Article] Crohn's Disease Risk Alleles on the NOD2 Locus Have Been Maintained by Natural Selection on Standing Variation

    • Author(s)
      S. Nakagome, S. Mano, L. Kozlowski, J. M. Bujnicki, H. Shibata, Y. Fukumaki, J. R. Kidd, K. K. Kidd, S. Kawamura, H. Oota
    • Journal Title

      Molecular Biology and Evolution

      Volume: (In press)

    • DOI

      doi:10.1093/molbev/mss006

    • Peer Reviewed
  • [Journal Article] The Asian Archival DNA Repository Consortium Autosomal and Y-chromosomal STR markers reveal a close relationship between Hokkaido Ainu and Ryukyu islanders

    • Author(s)
      K. Koganebuchi, T. Katsumura, S. Nakagome, H. Ishida, S. Kawamura, H. Oota
    • Journal Title

      Anthropological Science

      Volume: (In press)

    • DOI

      DOI:10.1537/ase.120322

    • Peer Reviewed
  • [Journal Article] Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits

    • Author(s)
      J-H. Park, T. Yamaguchi, C. Watanabe, A. Kawaguchi, K. Haneji, M. Takeda, Y-I. Kim, Y. Tomoyasu, M. Watanabe, H. Oota, T. Hanihara, H. Ishida, K. Maki, S-B. Park, R. Kimura
    • Journal Title

      Journal of Human Genetics

      Volume: (In press)

    • Peer Reviewed
  • [Presentation] 人類の形態、生理・代謝、疾患の進化に関するゲノム多様性研究2011

    • Author(s)
      太田博樹
    • Organizer
      統数研研究集会
    • Place of Presentation
      統計数理学研究所,立川
    • Year and Date
      20111219-19
  • [Presentation] Allelic Variations of Cytochrome P450 1B1 in Wild Medaka Populations : Curious Similarities to Humans' Polymorphisms and Their Functions2011

    • Author(s)
      T. Katsumura, S. Oda, H. Mitani, S. Kawamura, H. Oota
    • Organizer
      The 1st Strategic Meeting for Medaka Research
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      20111123-24
  • [Presentation] Population specific susceptibility to Crohn's disease and signals of natural selection on standing variation2011

    • Author(s)
      S. Nakagome, S. Mano, L. Kozlowski, J. M. Bujnicki, H. Shibata, Y. Fukumaki, J. R. Kidd, K. K. Kidd, S. Kawamura, H. Oota
    • Organizer
      The 12th ICHG/The 61th Annual Meeting of The American Society of Human Genetics
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      20111011-15
  • [Presentation] Allelic Variations of Cytochrome P450 Genes in Wild Medaka Populations : Curious Similarities to Humans' Polymorphisms and Their Functions2011

    • Author(s)
      T. Katsumura, S. Oda, H. Mitani, S. Kawamura, H. Oota
    • Organizer
      Isogenic Medaka Workshop
    • Place of Presentation
      EBI, Hinxton, UK
    • Year and Date
      20110926-27
  • [Presentation] Allelic variations of cytochrome P450 genes in wild medaka populations : a parallelism to human alleles2011

    • Author(s)
      勝村啓史、尾田正二、三谷啓志、河村正二、太田博樹
    • Organizer
      第13回日本進化学会
    • Place of Presentation
      京都大学百周年時計台記念館,京都
    • Year and Date
      20110729-31
  • [Presentation] Allelic Variations of Cytochrome P450 Genes in Wild Medaka Populations : a Parallelism to Human Alleles2011

    • Author(s)
      T. Katsumura, S. Oda, H. Mitani, S. Kawamura, H. Oota
    • Organizer
      The Society for Molecular Biology and Evolution, Annual Meeting
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20110726-30
  • [Presentation] Population specific distribution of Crohn's disease risk alleles on the NOD2 locus and natural selection on standing variation2011

    • Author(s)
      T. Nakagome, S. Mano, L. Kozlowski, J. M. Bujnicki, H. Shibata, Y. Fukumaki, J. R. Kidd, K. K. Kidd, S. Kawamura, H. Oota
    • Organizer
      The Society for Molecular Biology and Evolution, Annual Meeting
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20110726-30
  • [Presentation] An evolutionary study of human complex diseases2011

    • Author(s)
      S. Nakagome, S. Mano, L. Kozlowski, J. M. Bujnicki, J. R. Kidd, K. K. Kidd, S. Kawamura, H. Oota
    • Organizer
      Workshop on Evolutionary Analyses and Applications
    • Place of Presentation
      China
    • Year and Date
      20110607-20
  • [Presentation] How should we think of "population" in population genetics?2011

    • Author(s)
      H. Oota
    • Organizer
      A Japan-based Global Study of Racial Representation International Workshop.
    • Place of Presentation
      Japan
    • Year and Date
      20110122-23
  • [Presentation] 沖縄人が大和人より酒に強い理由-遺伝子を調べてわかったこと-2011

    • Author(s)
      太田博樹
    • Organizer
      第65回日本人類学会公開シンポジウムI
    • Place of Presentation
      那覇
    • Year and Date
      2011-11-06
  • [Presentation] How do physical anthropologists have committed themselves on genome medicine? Changing Representations of Indigenous and Migrant Groups in Globalizing Japan : Genes, Bones, and Cultures2011

    • Author(s)
      H. Oota
    • Organizer
      IUAES/AAS/ASAANZ Conference 2011
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2011-07-05
  • [Presentation] 環境要因と遺伝的多型と多様な表現型との関係/Environmental factors and relationship between genetic polymorphisms and various phenotypes2011

    • Author(s)
      太田博樹
    • Organizer
      第64回日本生理人類学会シンポジウムI
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-11
  • [Presentation] メダカ集団を用いたヒト多型の生体機能解析実験系の検討. cytochrome P450に着目して2011

    • Author(s)
      勝村啓史、尾田正二、三谷宏志、河村正二、太田博樹
    • Organizer
      第11回東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学本郷キャンパス,東京
    • Year and Date
      2011-06-04
  • [Presentation] メダカ地域集団間のCYP酵素活性の違い2010

    • Author(s)
      勝村啓史、尾田正二、三谷宏志、河村正二、太田博樹
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20101207-10
  • [Presentation] ヒト遺伝的多型の生体機能解析実験系の構築.メダカを用いた新たなアプローチ2010

    • Author(s)
      勝村啓史、尾田正二、三谷宏志、河村正二、太田博樹
    • Organizer
      第4回総研大ワークショップ
    • Place of Presentation
      相模原
    • Year and Date
      20101023-24
  • [Presentation] Alcohol dehydrogenase(ADH) gene cluster in primates2010

    • Author(s)
      H. Oota, R. Kaul, H. Shibata, A. Toyoda, A. Fujiyama, W. C. Speed, J. R. Kidd, M. Olson, S. Kawamura, K. K. Kidd
    • Organizer
      International Primatological Society XXIII Congress Kyoto 2010
    • Place of Presentation
      Japan
    • Year and Date
      20100912-18
  • [Presentation] An evolutionary analysis of the NOD2 gene associated with Crohn's disease2010

    • Author(s)
      S. Nakagome, S. Mano, J. R. Kidd, K. K. Kidd, S. Kawamura, H. Oota
    • Organizer
      The Society for Molecular Biology and Evolution, Annual Meeting
    • Place of Presentation
      Kyoto, France
    • Year and Date
      20100704-08
  • [Presentation] A study of functional differences between alleles in P450 genes for medaka fish(Oryzias latipes)2010

    • Author(s)
      T. Katsumura, S. Oda, H. Mitani, S. Kawamura, H. Oota
    • Organizer
      Genetics 2010 : model organisms to human biologymodel organisms to human biology
    • Place of Presentation
      Boston, U. S. A.
    • Year and Date
      20100612-15
  • [Presentation] ヒトCYP多型とメダカ地域集団を用いた生体機能解析2010

    • Author(s)
      勝村啓史、尾田正二、三谷啓志、河村正二、太田博樹
    • Organizer
      第1回CYP研究会
    • Place of Presentation
      葉山
    • Year and Date
      2010-11-17
  • [Presentation] 水田の拡散とメダカの移動2010

    • Author(s)
      勝村啓史、尾田正二、三谷宏志、河村正二、太田博樹
    • Organizer
      日本人類学会第64回大会
    • Place of Presentation
      伊達
    • Year and Date
      2010-10-03
  • [Presentation] ヒト遺伝的多型の機能解析実験モテル生物としての野生メタカ集団の有用性-cytochrome P450遺伝子に着目して2010

    • Author(s)
      勝村啓史、尾田正二、三谷宏志、河村正二、太田博樹
    • Organizer
      小型魚類研究会第16回大会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-09-19
  • [Presentation] 野生メダカ集団におけるcytochrome P450遺伝子のアレル間機能差2010

    • Author(s)
      勝村啓史、尾田正二、三谷宏志、河村正二、太田博樹
    • Organizer
      日本進化学会第12回大会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-03
  • [Presentation] ヒトの進化とゲノム多様性2010

    • Author(s)
      太田博樹
    • Organizer
      第20回日本解剖学会関東支部懇話会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-22
  • [Presentation] メダカ集団を用いたヒト遺伝的多型の生体機能解析実験系の開発2009

    • Author(s)
      勝村啓史、尾田正二、三谷啓志、河村正二、太田博樹
    • Organizer
      日本進化学会第11回大会
    • Place of Presentation
      札幌
    • Year and Date
      20090903-04
  • [Presentation] メダカ集団を用いたヒト遺伝的多型の生体機能解析実験系の構築2009

    • Author(s)
      勝村啓史、尾田正二、三谷啓志、河村正二、太田博樹
    • Organizer
      特別領域研究「ゲノム」4領域2009年度合同班会議
    • Place of Presentation
      神戸
    • Year and Date
      20090831-0901
  • [Presentation] Relationship between DNA Quantity and Amino Acid Racemization Rate in Ancient Biological Remains2009

    • Author(s)
      覚張隆史、太田博樹、大谷進、米田穣
    • Organizer
      日本分子生物学会第32回大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
  • [Presentation] Linkage disequilibrium analysis and specific polymorphisms to local human populations across Crohn's disease genomic regions2009

    • Author(s)
      中込滋樹、間野修平、竹山康章、向坂彰太郎、松井敏幸Judith R. Kidd、Kenneth K. Kidd、河村正二、太田博樹
    • Organizer
      日本分子生物学会第32回大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
  • [Presentation] Analysis of human polymorphisms in cytochrome P450 gene family using medaka(Oryzias latipes) local-wild populations2009

    • Author(s)
      勝村啓史, 尾田正二, 三谷啓志, 河村正二, 太田博樹
    • Organizer
      日本分子生物学会第32回大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
  • [Presentation] Linkage disequilibrium analysis of alcohol-metabolizing gene cluster and East Asian specific haplotypes2009

    • Author(s)
      小金渕佳江、松草博隆、中込滋樹、石田肇、埴原恒彦、副島英伸、藤本一眞、河村正二、太田博樹
    • Organizer
      日本分子生物学会第32回大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
  • [Presentation] A comparative genome analysis of the alcohol dehydrogenase gene cluster in primates2009

    • Author(s)
      太田博樹、R. Kaul, M. Olson, 柴田弘紀、河村正二、W. C. Speed、J. R. Kidd、K. K. Kidd
    • Organizer
      日本分子生物学会第32回大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
  • [Presentation] 性偏向的移住とヒトゲノム多様性日本人類学会2009

    • Author(s)
      太田博樹
    • Organizer
      第63回大会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-10-04
  • [Presentation] 歯形態の遺伝学:シャベル型切歯とEDAR2009

    • Author(s)
      木村亮介、山口徹太郎、槙宏太郎、武田摩耶子、近藤修、埴原恒彦、大沢資樹、石田肇、河村正二、太田博樹
    • Organizer
      日本人類学会第63回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-03
  • [Presentation] 日本人とヨーロッパ人におけるクローン病原因候補遺伝子の違い2009

    • Author(s)
      中込滋樹、竹山康章、間野修平、向坂彰太郎、松井敏幸、河村正二、太田博樹
    • Organizer
      日本人類学会第63回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-03
  • [Presentation] ADH1BおよびALDH2における琉球諸島vs北部九州ヒト集団の比較遺伝学解析2009

    • Author(s)
      小金渕佳江、松草博隆、中込滋樹、石田肇、埴原恒彦、副島英伸、藤本一眞、河村正二、太田博樹
    • Organizer
      日本人類学会第63回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-03
  • [Presentation] ADH1BおよびALDH2における琉球諸島vs北部九州ヒト集団の比較遺伝学解析2009

    • Author(s)
      小金渕佳江、松草博隆、中込滋樹、石田肇、埴原恒彦、副島英伸、藤本一眞、河村正二、太田博樹
    • Organizer
      日本人類遺伝学会第54回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-25
  • [Book] Ulcerative Colitis 22012

    • Author(s)
      S. Nakagome, H. Oota
    • Publisher
      InTech
  • [Book] Primatology Monographs2012

    • Author(s)
      H. Oota, K. K. Kidd
    • Total Pages
      149-161
    • Publisher
      Springer
  • [Book] Effects of Human Migration on Genome Diversity in East Asia2011

    • Author(s)
      H. Oota, M. Stoneking
    • Total Pages
      173-187
    • Publisher
      Kyoto University Pressand Trans Pacific Press
  • [Book] Human Population Genetics Meets Medaka2011

    • Author(s)
      H. Oota, H. Mitani
    • Total Pages
      339-350
    • Publisher
      Springer
  • [Book] 男女で異なる移住パターンとヒトゲノム多様性生物の科学遺伝2010

    • Author(s)
      太田博樹
    • Publisher
      NTS
  • [Remarks] 【アウトリーチ活動】沖縄県立博物館で開催された一般向け展示会「沖縄科学の最前線2010」にてポスター『沖縄本島・先島諸島の人々の遺伝子』展示

  • [Remarks] 東京大学大学院新領域創成科学研究科・太田研究室ホームページ

    • URL

      http://www.jinrui.ib.k.u-tokyo.ac.jp/oota/index.html

  • [Remarks] 北里大学医学部・太田研究室ホームページ

    • URL

      http://www.med.kitasato-u.ac.jp/~anatomy-anthropology/oota_lab/index.php

  • [Patent(Industrial Property Rights)] ヒトの唾液細菌叢を調べる方法及びそれに基づく消化器系疾患の診断2012

    • Inventor(s)
      服部正平、森田英利、太田博樹、知念寛
    • Industrial Property Rights Holder
      服部正平、森田英利、太田博樹、知念寛
    • Industrial Property Number
      特許、2012-050007
    • Filing Date
      2012-03-07

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Published: 2013-07-31  

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