2011 Fiscal Year Final Research Report
Structural biology for elucidation of lysine biosynthesis and its regulatory mechanisms
| Project/Area Number |
21380057
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NISHIYAMA Makoto 東京大学, 生物生産工学研究センター, 教授 (00208240)
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| Co-Investigator(Kenkyū-buntansha) |
TOMITA Takeo 東京大学, 生物生産工学研究センター, 助教 (50447364)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 微生物酵素 / 構造生物学 |
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| Research Abstract |
There are two different pathways in lysine biosynthesis. In this study, we have succeeded in elucidation of regulatory mechanisms of enzymes, each of which has a key role in each biosynthetic pathway. In the second half of lysine biosynthetic pathway throughα-aminoadipate, we discovered that a protein named LysW is not only used for modification of the amino group of the substrate, but also served as a carrier protein for biosynthetic enzymes.
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