2011 Fiscal Year Final Research Report
Study on the molecular mechanisms of the fungal cell-wallβ-1, 6-glucan biosynthesis
| Project/Area Number |
21380058
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YODA Koji 東京大学, 大学院・農学生命科学研究科, 教授 (20143406)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 微生物機能 / 酵母細胞壁 |
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| Research Abstract |
The molecular mechanism of biosynthesis ofβ-1, 6-glucan, an essential component of the yeast cell wall, is still unclear. Kre6 and its homologue Skn1, which have sequence homology with glycoside hydrolases, are required for this process. In this study, we discovered that Kre6 and Skn1 interact with the ER-resident proteins Keg1, a part of Kre6/Skn1 must localize to the plasma membrane of growing buds forβ-1, 6-glucan synthesis, and their proper folding and localization to the growing buds require support of Keg1 and Cne1 in the ER.
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