2011 Fiscal Year Final Research Report
Protein Engineering of vitamin D hydroxylases and design of their inhibitors based on their tertiary structure
| Project/Area Number |
21380067
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Toyama Prefectural University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hiroshi 理化学研究所, 城研, 研究員 (90344043)
KITTAKA Atsushi 帝京大学, 薬学部, 教授 (00214833)
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| Co-Investigator(Renkei-kenkyūsha) |
IKUSHIRO Shinichi 富山県立大学, 工学部, 准教授 (50244679)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ビタミンD / シトクロムP450 / 癌 / 骨粗鬆症 |
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| Research Abstract |
We have successfully generated a highly active actinomycete vitamin D hyroxylase to produce 3 hydroxylated forms of vitamin D which have potent biological activities based on its tertiary structure. In addition, we have successfully synthesized novel vitamin D analogues which show a potent anti-cancer activity and a remarkable metabolism-resistance in vivo.
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[Presentation] Novel C15-Substituted Active Vitamin D_3 Analogs : Design, Synthesis and Biological Activity2009
Author(s)
K Shindo, M Takano, G Kumagai, N Saito, H Saito, K Takagi, S Kakuda, M Takimoto-Kamimura, K Takenouchi, S Ishizuka, D Sawada and A Kittaka
Organizer
14th Vitamin D Workshop
Year and Date
20091004-08
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