2012 Fiscal Year Final Research Report
Bioorganic study on mycoparasitism by Lambertella spp.
| Project/Area Number |
21380069
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SONOKI Tomonori 弘前大学, 農学生命科学部, 准教授 (20502264)
TAKADA Oboru 弘前大学, 農学生命科学部, 准教授 (10332701)
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| Project Period (FY) |
2011 – 2012
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| Keywords | マイコパラサイト・lambertellols / 生分解活性化 |
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| Research Abstract |
Monilinia fructigena is sometimes replaced with Lambertella corni-maris on apple fruits, which is now considers as mycoparasitism. This phenomenon could be reproduced also on Petri dish. In this case each fungus is intermixed together without competitive inhibition. But we observed only Lambertella corni-maris from the dish after a couple of month. Thus we can not explain this phenomenon only with production of antibiotics.
Parasite Lambertella produces lambertelllols. These are diffusible on PSA mediu. Although, these are stable under weak acidic conditions, it became labile by increament of pH. We found that the host Monilinia makes its surroundings acidic to stabilize it. So, lambertellols can reach to Monilinia’s area. The degraded product is known lambertellin which shows potent antifungal activity, while lambertellols do not show that activity. It would be the mechanism for the fungal replacement without showing competitive inhibition. This mechanism accorded with that fact that lambertellin is always minor component. In the beginning we thought there is a mechanism to turn on anf off the production of lambertellin. We also succeeded in proving that by observing constant production of lambertellin by detecting its biodegradation product.
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Research Products
(88 results)
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[Journal Article] Isolation and absolute stereochemistry of optically active sydonic acid from from Glonium sp. (Hysteriales, Ascomycota)2009
Author(s)
Kudo, S., Murakami, T., Miyanishi, J., Tanaka, K., Takada, N., Hashimoto, M.
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Journal Title
Biosci. Biotech. Biochem
Volume: 73
Pages: 203-204
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[Presentation] Stereochemistry of Alterporriols
Author(s)
Saki Kanamaru, Shinji Kudo, Taro Tsushima, Ken-ichi Nihei, Tatsuo Nehira, Toshikatsu Okuno, Masaru Hashimoto
Organizer
2010 International Chemical Congress of Pacific Basin Societies
Place of Presentation
Honolulu, poster presentation
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