2011 Fiscal Year Final Research Report
Regulation of cystine/glutamate transporter by food-derived factors and its physiological functions
| Project/Area Number |
21380074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Yamagata University |
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Principal Investigator |
SATO Hideyo 山形大学, 農学部, 教授 (60235380)
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Kiharu 山形大学, 農学部, 教授 (00111336)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 食品 / グルタチオン / シスチン / トランスポーター / ネギ科植物 / 酸化ストレス |
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| Research Abstract |
In the present study, we have investigated the regulatory mechanism of cystine/glutamate transporter (xCT) by food-derived factors and the physiological functions. xCT is constitutively expressed in immune tissues including mesenteric lymph node and Payer's patch. Induction of xCT in macrophages has been demonstrated to be important for expressing the function of the cells. The extract derived from some species of Allium increased intracellular glutathione. This was due to the induction of xCT. Increased glutathione in islet cells by the extract from Allium plants seems to play a protective role against oxidative stress.
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[Journal Article] Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression2012
Author(s)
Lewerenz, J., Sato, H., Albrecht, P., Henke, N., Noack, R., Methner, A., Maher, P
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Journal Title
Cell Death & Differentiation
Volume: 19
Pages: 847-858
Peer Reviewed
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[Journal Article] Dopaminergic neurons of system xc-deficient mice are highly protected against 6-OHDA induced toxicity2011
Author(s)
Massie, A., Schallier, A., Kim, S-W., Fernando, R., Kobayashi, S., Beck, H., De Bundel, D., Vermoesen, K., Bannai, S., Conrad, M., Plesnila, N., Sato, H., Michotte, Y
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Journal Title
FASEB J
Volume: 25
Pages: 1359-1369
Peer Reviewed
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[Journal Article] Loss of system xc-does not induce oxidative stress but decrease extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility2011
Author(s)
De Bundel, D., Schallier, A., Loyens, E., Fernando, R., Miyashita, H., Van Liefferinge, J., Vermoesen, K., Bannai, S., Sato, H., Michotte, Y., Smolders, I., Massie, A
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Journal Title
J. Neurosci
Volume: 31
Pages: 5792-5803
Peer Reviewed
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[Journal Article] MMDB : Mouse multiple tissue metabolome database2011
Author(s)
Sugimoto, M., Ikeda, S., Niigata, K., Tomita, M., Sato, H., Soga, T
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Journal Title
Nucleic Acids Res
Pages: 1-6
Peer Reviewed
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[Journal Article] System XC-and thioredoxin reductase 1 cooperatively rescue glutathione deficiency2010
Author(s)
Mandal, P. K., Seiler, A., Perisic, T., Kolle, P., Canak, A. B., Forster, H., Weiss, N., Kremmer, E., Lieberman, M. W., Bannai, S., Kuhlencordt, P., Sato, H., Bornkamm, G. W., Conrad, M
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 22244-22253
Peer Reviewed
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