2011 Fiscal Year Final Research Report
Analysis of Molecular Mechanisms for Modulation of Immune-Regulatory Function of Intestinal Epithelia by Food Factors
| Project/Area Number |
21380077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TOTSUKA Mamoru 東京大学, 大学院・農学生命科学研究科, 准教授 (70227601)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腸管上皮細胞 / Toll様受容体 / 腸管免疫系 / IgA / サイトカイン / プロバイオティクス / カルノシン |
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| Research Abstract |
Function of food factors that modulate immune-regulatory functions of intestinal epithelial cells(IEC) was analyzed. Carnosine enhanced the cytokine secretion from IEC stimulated with bacterial components. The supernatant of the IEC upregulated IgA production by B cells derived from mouse lamina propria. Oral administration of carnosine increased the amount of IgA in mucosa of the mouse small intestine. We also found that bifidobacteria upregulated the expression of a transcytotic carrier protein for IgA in IEC, that oral administration of lactobacilli induced regulatory T cells and enhanced oral tolerance induction, and that naringenin has the capacity to induce regulatory T cells.
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