2011 Fiscal Year Final Research Report
Studies on physiological roles of ER-60 by tissue-specific gene targeting analysis
| Project/Area Number |
21380081
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
URADE Reiko 京都大学, 大学院・農学研究科, 教授 (90167289)
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| Co-Investigator(Kenkyū-buntansha) |
URADE Yoshihiro 大阪バイオサイエンス研究所, 研究部長 (10201360)
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| Co-Investigator(Renkei-kenkyūsha) |
KASHIWAGI Kahori 大阪バイオサイエンス研究所, 研究員 (10372666)
LAZARUS Michae 大阪バイオサイエンス研究所, 研究員 (80469650)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ER-60 / 小胞体 / 分子シャペロン / ノックアウトマウス / 小胞体ストレス / アミロイドβ / X線結晶構造解析 |
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| Research Abstract |
In this project, we found that the folding efficiency of some membrane glycoproteins was impaired by liver-specific knockout of ER-60. It was demonstrated that ER stress might be easily induced in ER-60 knockout mice by long feeding of high-fat diet. We attempted to confirm the protective effects of ER-60 against toxicity of amyloid beta peptides by brain-specific ER-60 knockout. In addition, we succeeded in X-ray structural analysis of a complex with the bb' fragment of ER-60 andβ-amyloid peptide.
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Research Products
(17 results)
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[Journal Article] High-Quality Protein Crystal Growth of Mouse Lipocalin-Type Prostaglandin D Synthase in Microgravity2011
Author(s)
Inaka K, Takahashi S, Aritake K, Tsurumura T, Furubayashi N, Yan B, Hirota E, Sano S, Sato M, Kobayashi T, Yoshimura Y, Tanaka H, Urade Y.
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Journal Title
Cryst. Growth Des
Volume: 11
Pages: 2107-2111
DOI
Peer Reviewed
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[Journal Article] Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens2011
Author(s)
Lazarus M, Shen HY, Cherasse Y, Qu W M, Huang Z L, Bass C E, Winsky-Sommerer R, Semba K, Fredholm B B, Boison D, Hayaishi O, Urade Y, Chen JF.
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Journal Title
J. Neurosci
Volume: 31
Pages: 10067-10075
DOI
Peer Reviewed
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[Journal Article] A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet2010
Author(s)
Ogasawara M, Ogasawara M, Hirose A, Ono M, Aritake K, Nozaki Y, Takahashi M, Okamoto N, Sakamoto S, Iwasaki S, Asanuma T, Taniguchi T, Urade Y, Onishi S, Saibara T, Oben JA
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Journal Title
Liver Int
Volume: 31
Pages: 542-551
DOI
Peer Reviewed
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