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2011 Fiscal Year Final Research Report

Study on the antitumor effect of vitamin B6

Research Project

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Project/Area Number 21380083
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionHiroshima University

Principal Investigator

KATO Norihisa  広島大学, 大学院・生物圏科学研究科, 教授 (20144892)

Co-Investigator(Kenkyū-buntansha) YANAKA Noriyuki  広島大学, 大学院・生物圏科学研究科, 准教授 (70346526)
MATSUBARA Kiminori  広島大学, 教育学研究科, 准教授 (90254565)
Project Period (FY) 2009 – 2011
KeywordsビタミンB6 / 抗腫瘍作用 / 遺伝子発現 / オートファジー / 炎症 / 大腸
Research Abstract

This study was performed to examine why the anti-tumor effect of vitamin B6 is profound in the colon. This reason was explained by indicating the higher sensitivity of colon levels of B6-vitamers to dietary supplemental vitamin B6. Further study with animals and colon cancer cells was conducted to examine the gene expression in response to vitamin B6. The results indicated the vitamin B6 altered the expression of genes relating to mast cells and cytotoxicT-cell activity and cytoprotection, which may lead to the anti-tumor effect

  • Research Products

    (20 results)

All 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (12 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Regulation of colon geneexpression by vitamin B6 supplementation2012

    • Author(s)
      Toya Keigo, Hirata Atsuko, OhataTomomi, Sanada Yohei
    • Journal Title

      Mol. Nutr. Food Res

      Volume: 56 Pages: 641-652

    • DOI

      DOI:10.1002/mnfr.201100707

    • Peer Reviewed
  • [Journal Article] Vitamin B6 suppressesserine protease inhibitor 3 expression inthe colon of rats and in TNF-α-stimulated HT-29 cells2011

    • Author(s)
      Noriyuki Yanaka, Tomomi Ohata, KeigoToya, Mayumi Kanda, Atsuko Hirata, Norihisa Kato
    • Journal Title

      Mol. Nutr. Food Res.

      Volume: 55 Pages: 635-645

    • DOI

      DOI:10.1002/mnfr.201000282

    • Peer Reviewed
  • [Journal Article] Consumption of vitamin B6 reduces colonicdamage and protein expression of HSP70and HO-1 in rats exposed to1, 2-dimethylhydrazine2011

    • Author(s)
      Kayashima Tomoko, Tanaka Kenta, Okazaki Yukako, Matsubara Kiminori, Yanaka Noriyuki, Kato Norihisa
    • Journal Title

      Oncol. Lett

      Volume: 2 Pages: 1243-1246

    • DOI

      DOI:10.3892/ol.2011.370

    • Peer Reviewed
  • [Journal Article] Vitamin B6 regulates mRNA expression of peroxisome proliferator-activatedreceptor-γtarget genes2011

    • Author(s)
      Yanaka Noriyuki, Kanda Mayumi, Toya Keigo, Suehiro Haruna, Kato Norihisa
    • Journal Title

      Exp. Ther. Med

      Volume: 2 Pages: 419-424

    • DOI

      DOI:10.3892/etm.2011.238

    • Peer Reviewed
  • [Journal Article] ビタミンB6のがん予防研究の新展開2010

    • Author(s)
      加藤範久
    • Journal Title

      ビタミン

      Volume: 84 Pages: 17-19

    • URL

      URL:http://web.kyoto-inet.or.jp/people/vsojkn/journal/index.html

    • Peer Reviewed
  • [Presentation] Inhibitory effect of vitamin B6, pyridoxal 5'-phosphate on lymphangiogenesis2012

    • Author(s)
      Matsubara Kiminori, Kato Norihisa
    • Organizer
      Advances and Controversies in B-Vitaminsand Choline
    • Place of Presentation
      Leipzig, Germany
    • Year and Date
      2012-03-06
  • [Presentation] Effect of dietary vitamin B6 on colonic luminal environment in rats2011

    • Author(s)
      Sofya Suidasari, Okazaki Yukako, ZakiUtama, Zhang Peipei, Ohsaki Aimi, YanakaNoriyuki, Tomotake Hiroyuki, KatoNorihisa
    • Organizer
      2011International Conference on Food Factors
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-11-21
  • [Presentation] Molecular mechanisms of anti-tumor effect of vitamin B62011

    • Author(s)
      Kato Norihisa
    • Organizer
      2011International Conference on Food Factors
    • Place of Presentation
      Taipei, tqiwan
    • Year and Date
      2011-11-20
  • [Presentation] ビタミンB6摂取に対する組織PLP,及びS1P濃度の応答2011

    • Author(s)
      ソフィアスイダサリ, カボマシシ, 矢中規之, 加藤範久
    • Organizer
      第43回日本栄養・食糧学会中四国支部大会
    • Place of Presentation
      高知
    • Year and Date
      2011-11-07
  • [Presentation] ビタミンB6による遺伝子発現変動の解析2011

    • Author(s)
      加藤範久
    • Organizer
      第426回ビタミンB研究協議会
    • Place of Presentation
      大津
    • Year and Date
      2011-11-05
  • [Presentation] Anti-tumor Effect of Dietary vitamin B6 and its me chanisms2011

    • Author(s)
      Kato Norihisa
    • Organizer
      International Conference on Cofactors 03
    • Place of Presentation
      Turku, Finland
    • Year and Date
      2011-07-14
  • [Presentation] Consumption of vtamin B6 modulates colonic luminal environment in rats fed a high-fat diet2011

    • Author(s)
      Okazaki Yukako, Zaki Utama, SofyaSuidasari, Zhang Peipei, Ohsaki Aimi, Yanaka Noriyuki, Tomotake Hiroyuki, Sakaguchi Ei, Kato Norihisa
    • Organizer
      International Conference on Cofactors 03
    • Place of Presentation
      Turku, Finland
    • Year and Date
      2011-07-13
  • [Presentation] ビタミンB6摂取に応答する大腸遺伝子発現のDNA microarray解析2011

    • Author(s)
      加藤範久
    • Organizer
      第424回ビタミンB研究協議会
    • Place of Presentation
      広島
    • Year and Date
      2011-06-03
  • [Presentation] ビタミンB6摂取量に対するマウス各臓器B6代謝物の応答の比較2011

    • Author(s)
      Masisi Kabo, Sofya Suidasari, 矢中規之, 加藤範久
    • Organizer
      日本栄養・食糧学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-14
  • [Presentation] Viamin B6の摂取が脂肪組織の遺伝子発現に及ぼす影響2011

    • Author(s)
      真田洋平, 矢中規之, 末廣春奈, 久本高央, 平田敦子, 西村英紀, 加藤範久
    • Organizer
      2011年度日本農芸化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-27
  • [Presentation] azoxymethane誘発大腸腫瘍モデルマウスの初期病変に関わる新規標的因子の同定,および抗癌活性を有するvitamin B6の予防効果に関する解析2010

    • Author(s)
      平田敦子, 真田洋平, 末廣春奈, 大畑智美, 矢中規之, 加藤範久
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
  • [Presentation] ビタミンB6摂取による大腸における遺伝子発現調節作用2010

    • Author(s)
      大畑智美, 矢中規之, 平田敦子, 真田洋平, 末廣春奈, 鳥家圭伍, 加藤範久
    • Organizer
      2010年度日本農芸化学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
  • [Book] Wageningen AcademicPublishers, Role of vitamin B6 in skin healthand diseases. Chapter 42012

    • Author(s)
      Kato Norihisa
    • Total Pages
      59-66
    • Publisher
      Handbook of diet, nutrition and the skin. ed. by Victor R. Reedy
  • [Book] ビタミン総合事典2010

    • Author(s)
      加藤範久,朝倉書店
    • Total Pages
      235-237
    • Publisher
      朝倉書店
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/nutri/index.htm

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Published: 2013-07-31  

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