2011 Fiscal Year Final Research Report
Basic and applied studies on immunobiotics by using intestinal peyer's patch model system of live stock animals
| Project/Area Number |
21380164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Tohoku University |
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Principal Investigator |
KITAZAWA Haruki 東北大学, 大学院・農学研究科, 准教授 (10204885)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Tadao 東北大学, 大学院・農学研究科, 教授 (00118358)
ASO Hisashi 東北大学, 大学院・農学研究科, 教授 (50241625)
KAWAI Yasushi 東北大学, 大学院・農学研究科, 助教 (00261496)
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| Project Period (FY) |
2009 – 2011
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| Keywords | イムノバイオティクス / 家畜 / ブタ / ウシ / 免疫 / 腸管上皮 / 腸管パイエル板 / 飼料 |
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| Research Abstract |
In this study, advanced immunobiotic assay systems for anti-inflammatory and anti-viral immunity was successfully developed by using originally established intestinal epithelial cells from live stock animals. The utility of these assay systems was verified by in vivo trial of selected immunobiotic candidate by these assay system in swine. This study may contribute to develop a safer technique without any drugs for livestock production.
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[Journal Article] A newly established bovine intestinal epithelial cell line is effective for in vitro screening of potential antiviral immunobiotic microorganisms for cattle2012
Author(s)
Chiba, E., J. Villena, S. Hosoya, N. Takanashi, T. Shimazu, H. Aso, M. Tohno, Y. Suda, Y. Kawai, T. Saito, K. Miyazawa, F. He, H. Kitazawa.
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Journal Title
Peer Reviewed
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[Journal Article] Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway2012
Author(s)
Shimazu, T., J. Villena, M. Tohno, H. Fujie , S. Hosoya, T. Shimosato, H. Aso, Y. Suda, Y. Kawai, T. Saito, S. Makino, S. Ikegami, H. Itoh, H. Kitazawa
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Journal Title
Infect. Immun.
Volume: 80
Pages: 276-288
Peer Reviewed
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[Journal Article] Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I : C)in porcine intestinal epithelial cells2011
Author(s)
Hosoya, S., J. Villena, T. Shimazu, M. Tohno, H. Fujie, E. Chiba, T. Shimosato, H. Aso, Y. Suda, Y. Kawai, T, Saito, S. Alvarez, S. Ikegami, H. Itoh, H. Kitazawa
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Journal Title
Vet. Res
Volume: 42(111)
Pages: 1-13
Peer Reviewed
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[Journal Article] Toll-like receptor-2 activating bifidobacteria strains differentially regulate inflammatory cytokines in porcine intestinal epithelial cell culture system : finding new anti-inflammatory immunobiotics2011
Author(s)
Fujie, H., J. Villena, M. Tohno, K. Morie, T. Shimazu, H. Aso, Y. Suda, T. Shimosato, N. Iwabuchi, J. Z. Xiao, T. Yaeshima, K. Iwatsuki, T. Saito, M. Numasaki, H. Kitazawa
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Journal Title
FEMS Immunol. Med. Microbiol
Volume: 63
Pages: 129-139
Peer Reviewed
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[Journal Article] Molecular cloning, tissue expression, and subcellular localization of porcine peptidoglycan recognition proteins 3 and 42011
Author(s)
Ueda, W., M. Tohno, T. Shimazu, H. Fujie, H. Aso, Y. Kawai, M. Numasaki, T. Saito, H. Kitazawa
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Journal Title
Vet. Immunol. Immunopathol
Volume: 143
Pages: 148-154
Peer Reviewed
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[Journal Article] Cytokeratin 18 is a specific marker of bovine intestinal microfold (M)cell2011
Author(s)
Hondo, T., T. Kanaya, I. Takakura, H. Watanabe, Y. Takahashi, Y. Nagasawa, S. Terada, S. Ohwada, K. Watanabe, H. Kitazawa, M. Rose, T. Yamaguchi, H. Aso
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Journal Title
Am. J. Physiol-Gastrointestinal and Liver Physiology
Volume: 300
Pages: G442-G453
Peer Reviewed
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