Clarification of new regulatory mechanisms of prolactin secretion by salsolinol and its physiological actions in ruminants

2011 Fiscal Year Final Research Report

• Project/Area Number: 21380169
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied animal science
• Research Institution: Iwate University
• Principal Investigator: HASHIZUME Tsutomu 岩手大学, 農学部, 教授 (60124533)
• Co-Investigator(Renkei-kenkyūsha): KASUYA Etsuko (独)農業生物資源研究所, 研究員 (90355743)
• Project Period (FY): 2009 – 2011
• Keywords: 生産機能制御

Research Abstract

The effects of salsolinol (SAL) on the secretion of prolactin (PRL) were examined in ruminants.SAL was able to stimulate the release of PRL not only in male and female calves, but also in adult cows. The seasonal effects on PRL-releasing response to SAL were observed in goats, and a long photo period enhanced the PRL-releasing response to SAL in goats. A dopamine agonist inhibited the SAL-induced PRL release in goats. These results show that SAL is a potent physiological PRL-releasing factor in ruminants.

Research Products

• [Journal Article] Effects of photoperiod on the secretion of growth hormone in female goats (2012)
  • Author(s): Jin J., Yaegashi T., Sawai K., Hashizume T
  • Journal Title: Animal Science Journal Volume: (in press)
  • DOI: Doi:10.1111/j.1740-0929.2011.00998.x
  • Peer Reviewed
• [Journal Article] Effects of photoperiod on salsolinol-induced prolactin secretion in goats (2012)
  • Author(s): Yaegashi T., Jin J., Sawada T., Saito H., Ful.p F., Nagy G.M., Hashizume T
  • Journal Title: Animal Science Journal Volume: 83 Pages: 63-67
  • Peer Reviewed
• [Journal Article] Bromocriptine inhibits salsolinol-induced prolactin release in male goats (2012)
  • Author(s): Hashizume T., Sawada T., Nakajima Y., Yaegashi T., Saito H., Goto Y., Jin J., Ful. p F., Nagy G.M.
  • Journal Title: Animal Science Journal Volume: 83 Pages: 63-67
  • Peer Reviewed
• [Journal Article] Ference FULOP, Gy.rgy Miklos Nagy,橋爪力雄ヤギにおけるサルソリノールによるプロラクチン放出反応 (2011)
  • Author(s): 澤田建, 中嶋侑佳, 八重樫朋祥, 斉藤隼人, 後藤由希, 金金, 澤井健
  • Journal Title: 東北畜産学会報 Volume: 63 Pages: 116-122
  • Peer Reviewed
• [Journal Article] Characteristics of prolactin-releasing response to salsolinol in vivo in cattle (2010)
  • Author(s): Hashizume T., Sawada T., Yaegashi T., Saito H., Ezzat Ahmed A., Goto Y., Nakajima Y., Jin J., Kasuya E., Nagy G.M
  • Journal Title: Domestic Animal Endocrinology Volume: 39 Pages: 21-25
  • Peer Reviewed
• [Presentation] Salsolinolにより誘起されるヤギのプロラクチン分泌に及ぼすL-dopaとCarbidopaの影響 (2012)
  • Author(s): 橋爪力,齋藤祐奈,遊佐瞳,後藤由希,金金,大場梨絵,澤井健
  • Organizer: 日本畜産学会第115大会
  • Place of Presentation: 名古屋,名古屋大学
  • Year and Date: 20120328-30
• [Presentation] 長日条件下でのメラトニン処理がSalsolinolによるヤギのプロラクチン放出反応に及ぼす影響 (2011)
  • Author(s): 橋爪力,八重樫朋祥,金金,後藤由希,遊佐瞳,澤井健
  • Organizer: 第104回日本繁殖生物学会
  • Place of Presentation: 盛岡市,アイーナ
  • Year and Date: 20110913-17
• [Presentation] 成熟雄ヤギと雄子ヤギにおけるSalsolinolによるプロラクチン分泌反応 (2011)
  • Author(s): 遊佐瞳,後藤由希,金金,澤井健,橋爪力
  • Organizer: 日本畜産学会第115大会
  • Place of Presentation: 十和田市,北里大学
  • Year and Date: 20110826-27
• [Presentation] Salsolinolにより誘起されるヤギのプロラクチン分泌に及ぼすL-DOPAの影響 (2011)
  • Author(s): 澤田建,八重樫朋祥,遊佐瞳,後藤由希,金金,澤井健,橋爪力
  • Organizer: 日本畜産学会第115大会
  • Place of Presentation: 十和田市,北里大学
  • Year and Date: 20110826-27
• [Presentation] 雄ヤギとSalsolinolによるプロラクチン分泌反応 (2010)
  • Author(s): 澤田建,中嶋侑佳,八重樫朋祥,斉藤隼人,後藤由希,金金,澤井健,橋爪力
  • Organizer: 第103回日本繁殖生物学会
  • Place of Presentation: 十和田市,北里大学
  • Year and Date: 20100901-04
• [Presentation] 日長および温度変化とSalsolinolによるヤギのプロラクチン分泌反応 (2010)
  • Author(s): 八重樫朋祥,金金,澤田建,斉藤隼人,後藤由希,中嶋侑佳,澤井健,橋爪力
  • Organizer: 第103回日本繁殖生物学会
  • Place of Presentation: 十和田市,北里大学
  • Year and Date: 20100901-04
• [Presentation] Salsolinolによる反芻家畜の新しいプロラクチン分泌支配機構に関する研究 (2010)
  • Author(s): 澤田建,中嶋侑佳,八重樫朋祥,斉藤隼人,後藤由希,金金,澤井健,橋爪力
  • Organizer: 第60回東北畜産学会
  • Place of Presentation: 盛岡市,アイーナ
  • Year and Date: 20100829-30
• [Presentation] In vivo characteristics of salsolinol on the secretion of prolactin in ruminants (2010)
  • Author(s): Hashizume T., Sawada T., Yaegashi T., Saito H., Nakajima Y., Goto Y., Ezzat Ahmed A., Jin J., Sawai K., Kasuya E., Nagy, G.M
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 20100326-30
• [Presentation] ウシの生殖生理と関連した新しい下垂体ホルモン分泌因子 (2010)
  • Author(s): 橋爪力
  • Organizer: FAMS生産科学セミナー(招待講演)
  • Place of Presentation: 盛岡市,岩手大学
  • Year and Date: 2010-11-04
• [Presentation] 日長変化とSalsolinolによるヤギのプロラクチン分泌反応に関する研究 (2009)
  • Author(s): Hashizume T., Sawada T., Yaegashi T., Saito H., Ezzat Ahmed A., Goto Y., Nakajima Y., Jin J., Kasuya E., Nagy G.M八重樫朋祥,澤田建,中嶋侑佳,金金,斉藤隼人,後藤由希,Ahmed Ezzat Ahmed,澤井健,橋爪力
  • Organizer: 第102回日本繁殖生物学会
  • Place of Presentation: 奈良,近畿大学
  • Year and Date: 20090910-12
• [Presentation] 成熟雄ヤギ及び分娩後の雌ウシにおけるSalsolinolによるプロラクチン分泌 (2009)
  • Author(s): 澤田建,中嶋侑佳,八重樫朋祥,斉藤隼人,後藤由希,金金,Ahmed Ezzat Ahmed,澤井健,橋爪力
  • Organizer: 第102回日本繁殖生物学会
  • Place of Presentation: 奈良,近畿大学
  • Year and Date: 20090910-12
• [Remarks]
  • URL: http://sp2.cc.iwate-u.ac.jp/~hashi/