2012 Fiscal Year Final Research Report
Studies on the mechanism of antimicrobial peptide synthesis for a strategy to enhance the innate immunity in hen oviduct
| Project/Area Number |
21380174
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISOBE Naoki 広島大学, 大学院・生物圏科学研究科, 准教授 (80284230)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 鳥類 / 卵管 / 自然免疫 / 抗菌ペプチド / 粘膜バリア |
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| Research Abstract |
The aim of this study was to determine the host defense functions by innate immune system in the hen oviduct. The results showed the first defense systemwas formed by mucosal barrier with mucin layer and epithelial cell tight junctions, induction of immunoresponse by cytokines, and synthesis of avian β-defensins (AvBDs). Decline of mucosal barrier system in molting birds was likely to be one of the reasons whyinfectious risk increases in them. The current study suggested a new mechanism by which AvBDs are induced, namely IL1β upregulates the expression of some AvBDs.
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Research Products
(8 results)
