2011 Fiscal Year Final Research Report
Analysis of lethal pathogenicity mechanism of herpesvirus in non-natural host
| Project/Area Number |
21380179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Gifu University |
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Principal Investigator |
FUKUSHI Hideto 岐阜大学, 応用生物科学部, 教授 (10156763)
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| Co-Investigator(Kenkyū-buntansha) |
OHYA Kenji 岐阜大学, 応用生物科学部, 准教授 (50402219)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMURA Tomio 日本中央競馬会競走馬総合研究所, 栃木支所, 室長 (20446511)
TSUJIMURA Koji 日本中央競馬会競走馬総合研究所, 栃木支所, 室員 (50446514)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 病原微生物 |
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| Research Abstract |
The object of this research is to reveal the molecular mechanism of herpesvirus lethal encephalitis in non-natural host. Equine herpesviruses(EHVs) 1 and 9 were used. Virus genes involving in the lethal encephalitis in non-natural host were identified. Comparison of neuropathogenic and non-neuropathogenic EHV-1s showed nine gene differences between their whole genome sequences. Comprehensive transcriptome analysis in EHV-infected cells were examined. Several viral and host genes were identified as variable transcript encoded genes in EHV-infected cells.
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Research Products
(11 results)
