2011 Fiscal Year Final Research Report
Studies of the roles of pituitary transcription factors for pituitary development and progenitor cells
| Project/Area Number |
21380184
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Meiji University |
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Principal Investigator |
KATO Yukio 明治大学, 農学部, 教授 (30114177)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Takako 明治大学, 研究知財, 研究員 (90445859)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 転写調節因子 / ホメオティック因子 / 性腺刺激ホルモン / 転写因子ネットワーク / 相互作用 / クローニング |
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| Research Abstract |
This study aimed to understand how homeotic transcription factors develop anterior pituitary and provide abilities to produce several hormones and regenerate hormone-producing cells throughout the life. By several approaches of molecular biology, cell biology and immunohistochemistry, we demonstrated that a pituitary specific transcription factor PROP1 and novel pituitary factors PRX1/PRX2 are indispensable for the pituitary organogenesis. To clarify the molecular functions are remained to be resolved in near future.
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