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2011 Fiscal Year Final Research Report

Basic study on mechanisms of metacyclogenesis-related vector-parasite relationships

Research Project

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Project/Area Number 21380186
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

INOUE Noboru  帯広畜産大学, 原虫病研究センター, 教授 (10271751)

Co-Investigator(Kenkyū-buntansha) KAWAZU Shin-ichiro  帯広畜産大学, 原虫病研究センター, 教授 (60312295)
GOTO Yasuyuki  東京大学, 大学院・農学生命科学研究科, 准教授 (50553434)
Co-Investigator(Renkei-kenkyūsha) SUGIMOTO Chihiro  北海道大学, 人獣共通感染症リサーチセンター, 教授 (90231373)
WATANABE Jyunichi  東京大学, 医科学研究所, 助教 (20201189)
KURATA Shouichiro  東北大学, 薬学研究科, 教授 (90221944)
Project Period (FY) 2009 – 2011
Keywords疾病予防・制御 / ツェツェバエ / アフリカトリパノソーマ / 生活環 / 遺伝子転写翻訳制御
Research Abstract

The world's first whole life-cycle stage proteome and EST data bases were established. These databases could potentially promote basic studies on control measures of human and animal African trypanosomoses. In addition, identification, cloning and characterization of congolense epimastigote specific protein (CESP) provided a novel knowledge which enhances further studies on trypanosome control strategies in its vector insect, tsetse.

  • Research Products

    (20 results)

All 2013 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (9 results) Book (2 results)

  • [Journal Article] アフリカトリパノソーマの遺伝子発現調節機構2013

    • Author(s)
      菅沼啓輔、井上昇
    • Journal Title

      獣医寄生虫学会誌

      Volume: 11 Pages: 87-92

    • Peer Reviewed
  • [Journal Article] The epimastigote stage-specific gene expression of CESP is tightly regulated by its 3'UTR2012

    • Author(s)
      Suganuma, K., Yamasaki, S., Asada, M., Kawazu, S. and Inoue, N.
    • Journal Title

      Molecular and Biochemical Parasitology

      Volume: 186 (1) Pages: 77-80

    • DOI

      DOI:10.1016/j.molbiopara.2012.09.010

    • Peer Reviewed
  • [Journal Article] Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection2012

    • Author(s)
      Mekata, H., Konnai, S., Mingala, C. N., Abes, N. S., Gutierrez, C. A., Dargantes, A. P., Witola, W. H., Inoue, N., Onuma, M., Murata, S. and Ohashi. K.
    • Journal Title

      Parasite Immunology

      Volume: 34 (6) Pages: 318-329

    • DOI

      DOI:10.1111/j.1365-3024.2012.01362.x

    • Peer Reviewed
  • [Journal Article] Structural characterization and epitope mapping of the Glutamic Acid/Alanine Rich protein from Trypanosoma congolense : Defining assembly on the parasite cell surface2011

    • Author(s)
      Loveless, B. C., Mason, J.W., Sakurai, T., Inoue, N., Razavi, M., Pearson, T. W. and Boulanger, M. J.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286(23) Pages: 20658-20665

    • DOI

      DOI:10.1074/jbc.M111.218941

    • Peer Reviewed
  • [Journal Article] Differential protein expression throughout the life cycle of Trypanosoma congolense, a major parasite of cattle in Africa2011

    • Author(s)
      Eyford, B. A., Sakurai, T., Smith, D., Loveless, B. C., Hertz-Fowler, C., Donelson, J. E., Inoue, N. and Pearson, T. W.
    • Journal Title

      Molecular & Biochemical Parasitology

      Volume: 177 (2) Pages: 116-125

    • DOI

      DOI:10.1016/j.molbiopara.2011.02.009

    • Peer Reviewed
  • [Journal Article] Biased cellular locations of tandem repeat antigens in African trypanosomes2011

    • Author(s)
      Goto, Y., Duthie, M. S., Kawazu, S., Inoue, N. and Carter, D.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 405 (3) Pages: 434-438

    • DOI

      DOI:10.1016/j.bbrc.2011.01.048

    • Peer Reviewed
  • [Journal Article] Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies2010

    • Author(s)
      Nakamura, K., Fujioka, S., Fukumoto, S., Inoue, N., Sakamoto, K., Hirata, H., Kido, Y., Yabu, Y., Suzuki, T., Watanabe, Y., Saimoto, H., Akiyama, H. and Kita, K.
    • Journal Title

      Parasitology International

      Volume: 59 (4) Pages: 560-564

    • DOI

      DOI:10.1016/j.parint.2010.07.006

    • Peer Reviewed
  • [Journal Article] Upregulated expression of B-cell antigen family tandem repeat proteins by Leishmania amastigotes2010

    • Author(s)
      Goto, Y., Carter, D., Guderian, J., Inoue, N., Kawazu, S. and Reed, S. G.
    • Journal Title

      Infection and Immunity

      Volume: 78 (5) Pages: 2138-2145

    • DOI

      DOI:10.1128/IAI.01102-09

    • Peer Reviewed
  • [Journal Article] Analysis of expressed sequence tags from the four main developmental stages of Trypanosoma congolense2009

    • Author(s)
      Helm, J. R., Hertz-Fowler, C., Aslett, M., Berriman, M., Sanders, M., Quail, M. A., Soares, M. B., Bonaldo, M. F., Sakurai, T., Inoue, N. and Donelson, J. E.
    • Journal Title

      Molecular and Biochemical Parasitology

      Volume: 168 (1) Pages: 34-42

    • DOI

      DOI:10.1016/j.molbiopara.2009.06.004

    • Peer Reviewed
  • [Presentation] Trypanosoma congolense EMF特異的遺伝子cespの発現調節領域の特定2013

    • Author(s)
      菅沼啓輔
    • Organizer
      第20回分子寄生虫ワークショップ
    • Place of Presentation
      神戸
    • Year and Date
      20130826-29
  • [Presentation] Analysis of the cis-element for gene expression regulation in congolense epimastigote specific protein (CESP)2013

    • Author(s)
      Suganuma, K.
    • Organizer
      The 24^<th> International Conference of the World Association for the Advancement of Veterinary Parasitology
    • Place of Presentation
      パース・オーストラリア
    • Year and Date
      20130825-29
  • [Presentation] Trypanosoma congolense EMFステージ特異的遺伝子の発現調節機構2013

    • Author(s)
      菅沼啓輔
    • Organizer
      第155回日本獣医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20130328-30
  • [Presentation] アフリカトリパノソーマ細胞表面分子による宿主認識とトロピズム2011

    • Author(s)
      井上昇
    • Organizer
      第4回原虫感染免疫研究会
    • Place of Presentation
      長崎
    • Year and Date
      2011-02-04
  • [Presentation] 新たに同定したアフリカトリパノソーマのツェツェバエ体内ステージ特異的表面分子CESPについて2010

    • Author(s)
      井上昇
    • Organizer
      第63回日本寄生虫学会南日本支部会・第60回日本衛生動物学会南日本支部会合同大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-11-06
  • [Presentation] Trypanosoma congolense CESPの多型解析2009

    • Author(s)
      竹本知代
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      鳥取
    • Year and Date
      20090925-27
  • [Presentation] Trypanosoma congolense (Tc)のツェツェバエ体内におけるCESP発現パターンの解析2009

    • Author(s)
      菅沼啓輔
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      鳥取
    • Year and Date
      20090925-27
  • [Presentation] Trypanosoma congolense EMF虫体特異的表面蛋白(CESP)の多型解析2009

    • Author(s)
      竹本知代
    • Organizer
      第17回分子寄生虫ワークショップ
    • Place of Presentation
      群馬
    • Year and Date
      20090806-09
  • [Presentation] Trypanosoma congolense (Tc)のツェツェ体内におけるCESP発現パターンの解析2009

    • Author(s)
      菅沼啓輔
    • Organizer
      第17回分子寄生虫ワークショップ
    • Place of Presentation
      群馬
    • Year and Date
      20090806-09
  • [Book] 改訂版人獣共通感染症2011

    • Author(s)
      井上昇(分担執筆)
    • Total Pages
      390-400
    • Publisher
      医薬ジャーナル社
  • [Book] 動物の感染症第三版2011

    • Author(s)
      井上昇(分担執筆)
    • Total Pages
      144
    • Publisher
      近代出版

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Published: 2014-08-29  

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