2011 Fiscal Year Final Research Report
Basic study on mechanisms of metacyclogenesis-related vector-parasite relationships
| Project/Area Number |
21380186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
INOUE Noboru 帯広畜産大学, 原虫病研究センター, 教授 (10271751)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAZU Shin-ichiro 帯広畜産大学, 原虫病研究センター, 教授 (60312295)
GOTO Yasuyuki 東京大学, 大学院・農学生命科学研究科, 准教授 (50553434)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Chihiro 北海道大学, 人獣共通感染症リサーチセンター, 教授 (90231373)
WATANABE Jyunichi 東京大学, 医科学研究所, 助教 (20201189)
KURATA Shouichiro 東北大学, 薬学研究科, 教授 (90221944)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 疾病予防・制御 / ツェツェバエ / アフリカトリパノソーマ / 生活環 / 遺伝子転写翻訳制御 |
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| Research Abstract |
The world's first whole life-cycle stage proteome and EST data bases were established. These databases could potentially promote basic studies on control measures of human and animal African trypanosomoses. In addition, identification, cloning and characterization of congolense epimastigote specific protein (CESP) provided a novel knowledge which enhances further studies on trypanosome control strategies in its vector insect, tsetse.
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Research Products
(20 results)
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[Journal Article] Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection2012
Author(s)
Mekata, H., Konnai, S., Mingala, C. N., Abes, N. S., Gutierrez, C. A., Dargantes, A. P., Witola, W. H., Inoue, N., Onuma, M., Murata, S. and Ohashi. K.
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Journal Title
Parasite Immunology
Volume: 34 (6)
Pages: 318-329
DOI
Peer Reviewed
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[Journal Article] Structural characterization and epitope mapping of the Glutamic Acid/Alanine Rich protein from Trypanosoma congolense : Defining assembly on the parasite cell surface2011
Author(s)
Loveless, B. C., Mason, J.W., Sakurai, T., Inoue, N., Razavi, M., Pearson, T. W. and Boulanger, M. J.
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Journal Title
The Journal of Biological Chemistry
Volume: 286(23)
Pages: 20658-20665
DOI
Peer Reviewed
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[Journal Article] Differential protein expression throughout the life cycle of Trypanosoma congolense, a major parasite of cattle in Africa2011
Author(s)
Eyford, B. A., Sakurai, T., Smith, D., Loveless, B. C., Hertz-Fowler, C., Donelson, J. E., Inoue, N. and Pearson, T. W.
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Journal Title
Molecular & Biochemical Parasitology
Volume: 177 (2)
Pages: 116-125
DOI
Peer Reviewed
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[Journal Article] Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies2010
Author(s)
Nakamura, K., Fujioka, S., Fukumoto, S., Inoue, N., Sakamoto, K., Hirata, H., Kido, Y., Yabu, Y., Suzuki, T., Watanabe, Y., Saimoto, H., Akiyama, H. and Kita, K.
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Journal Title
Parasitology International
Volume: 59 (4)
Pages: 560-564
DOI
Peer Reviewed
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[Journal Article] Upregulated expression of B-cell antigen family tandem repeat proteins by Leishmania amastigotes2010
Author(s)
Goto, Y., Carter, D., Guderian, J., Inoue, N., Kawazu, S. and Reed, S. G.
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Journal Title
Infection and Immunity
Volume: 78 (5)
Pages: 2138-2145
DOI
Peer Reviewed
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[Journal Article] Analysis of expressed sequence tags from the four main developmental stages of Trypanosoma congolense2009
Author(s)
Helm, J. R., Hertz-Fowler, C., Aslett, M., Berriman, M., Sanders, M., Quail, M. A., Soares, M. B., Bonaldo, M. F., Sakurai, T., Inoue, N. and Donelson, J. E.
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Journal Title
Molecular and Biochemical Parasitology
Volume: 168 (1)
Pages: 34-42
DOI
Peer Reviewed
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