2011 Fiscal Year Final Research Report
Molecular analysis of resistant mechanisms against both hypoxic and pro-apoptotic stimulation in malignant hematopoietic cell tumors.
| Project/Area Number |
21380194
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
TANAKA Akane 東京農工大学, 大学院・農学研究院, 教授 (80418673)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Hiroshi 東京農工大学, 大学院・農学研究院, 教授 (80145820)
OHMORI Keitaro 東京農工大学, 大学院・農学研究院, 講師 (20466915)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肥満細胞腫 / リンパ腫 / 白血病 / 伴侶動物 / 細胞増殖 |
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| Research Abstract |
he malignant acquired character that is the most serious in the tumor development of the cell is the abnormal proliferation and apoptosis resistance by the disablement of the cell death signal. In this study, I analyzed the disablement mechanism of the endogenous apoptotic process dependent on the mitochondria in the haematopoietic malignant tumor and cell function maintenance mechanism under the hypoxia environment. I also searched for the molecular target medicine which showed anti-cancer property. The crosstalk of the hypoxia-inducible factor(HIF) and NF-κB resulting in apoptosis resistance was investigated.
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[Journal Article] Peroxisome proliferator-activated receptorγ-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice2011
Author(s)
Jung K, Tanaka A, Fujita H, Matsuda A, Oida K, Karasawa K, Okamoto N, Ohmori K, Jee Y, Shin T, Matsuda H.
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Journal Title
J Allergy Clin Immunol
Volume: 127
Pages: 420-429
DOI
Peer Reviewed
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[Journal Article] Glucocorticoid sensitivity depends on expression levels of glucocorticoid receptors in canine neoplastic mast cells2011
Author(s)
Matsuda A, Tanaka A, Amagai Y, Ohmori K, Nishikawa S, Xia Y, Karasawa K, Okamoto N, Oida K, Jang H, Matsuda H.
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Journal Title
Vet Immunol Immunopathol
Volume: 144
Pages: 321-328
DOI
Peer Reviewed
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[Journal Article] A novel NF-kappa B inhibitor improves glucocorticoid sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors2010
Author(s)
Matsuda A, Tanaka A, Muto S, Ohmori K, Furusaka T, Jung K, Karasawa K, Okamoto N, Oida K, Itai A, Matsuda H.
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Journal Title
Res Vet Sci
Volume: 89
Pages: 378-382
Peer Reviewed
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