2011 Fiscal Year Final Research Report
The development of innovative asy mmetric synthetic methods by the enzyme-metal combo catalysis
| Project/Area Number |
21390005
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
AKAI Shuji 静岡県立大学, 薬学部, 教授 (60192457)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 不斉合成 / 動的光学分割 / 加水分解酵素 / オキソバナジウム / アリルアルコール / メソポーラスシリカ / 転位反応 / 固定化触媒 |
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| Research Abstract |
A new methodology for the conversion of racemic allyl alcohols into optically pure compounds was devised by the combined use of hydrolases and vanadium compounds. The results of this project present an innovative concept for the asymmetric synthesis of optically active compounds which is essential for the drug discovery research. It is noteworthy that in order to fulfill the original functions of the two highly reactive catalysts ; viz., enzymes and the oxovanadium compound, without mutual deactivation in a single reaction vessel, mesoporous silica was effectively employed to divide their work space.
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