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2013 Fiscal Year Final Research Report

Immune-suppressive function of cancer-associated mucin epiglycanin/Muc21

Research Project

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Project/Area Number 21390018
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

IRIMURA Tatsuro  東京大学, 薬学研究科(研究院), 名誉教授 (80092146)

Project Period (FY) 2009-04-01 – 2013-03-31
Keywordsムチン / 免疫抑制 / がん / エピグリカニン / アポトーシス
Research Abstract

Biological and immunological behaviors of transfectants with mouse or human epiglycanin/MUC21 were investigated and the contribution of glycoforms was assessed. Tansfectants of mouse Muc21 were shown to be less adherent than mock transfectants to culture substrates and extracellular matrix components. These properties were due to interference of integrin functions. The transfectants were less sensitive to treatment with cytotoxic effects. These properties may explain the reason why cells with high Muc21 expression were resistant to immunological cancer surveillance. Similar properties such as resistance to apoptosis were observed with cells transfected with human MUC21.

  • Research Products

    (49 results)

All 2013 2012 2011 2010

All Journal Article (25 results) Presentation (24 results)

  • [Journal Article] Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices2013

    • Author(s)
      Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka T, Hayakawa Y, Nakajima M, Irimura T
    • Journal Title

      Biochem J

      Volume: (published online)

  • [Journal Article] A unique dermal dendritic cell subset that skews the immune response toward Th22013

    • Author(s)
      Murakami R, Denda-Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T
    • Journal Title

      PLoS One

      Volume: 8(9) Pages: e73270

  • [Journal Article] Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model2013

    • Author(s)
      Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsukada K, Irimura, T, Shibahara N, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K
    • Journal Title

      Oncol Rep

      Volume: 29 Pages: 975-982

  • [Journal Article] Functional roles of TRAIL-DR5 interaction in B16F10 by activating NFκB pathway to induce metastatic potential2013

    • Author(s)
      Takahashi K, Takeda K, Saiki I, Irimura T, Hayakawa Y
    • Journal Title

      Cancer Sci

      Volume: 104(5) Pages: 558-562

  • [Journal Article] Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1alpha–MUC1 pathway2013

    • Author(s)
      Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J
    • Journal Title

      Cancer Letter

      Volume: 339(1) Pages: 82-92

  • [Journal Article] Monocyte differentiation induced by co-culture with tumor cells involves RGD-dependent cell adhesion to extracellular matrix2012

    • Author(s)
      Kamoshida G, Matsuda A, Sekine W, Mizuno H, Oku T, Itoh S, Irimura T, Tsuji T
    • Journal Title

      Cancer Lett

      Volume: 315(2) Pages: 145-152

  • [Journal Article] Cell surface expression of hyaluronan on human ovarian cancer cells inversely correlates with their adhesion to peritoneal mesothelial cells2012

    • Author(s)
      Tamada Y, Takeuchi H, Suzuki N, Aoki D, Irimura T
    • Journal Title

      Tumour Biol

      Volume: 33(4) Pages: 1215-1222

  • [Journal Article] Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation2012

    • Author(s)
      Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M
    • Journal Title

      Eur J Immunol

      Volume: 42(4) Pages: 936-945

  • [Journal Article] Mucin 21 in esophageal squamous epithelia and carcinomas : analysis with glycoform-specific monoclonal antibodies2012

    • Author(s)
      Tian Y, Denda-Nagai K, Kamata-Sakurai M, Nakamori S, Tsukui T, Itoh Y, Okada K, Yi Y, Irimura T
    • Journal Title

      Glycobiology

      Volume: 22(9) Pages: 1218-1226

  • [Journal Article] Establishment of PI3K inhibitor-resistant cancer cell lines and the therapeutic strategies for overcoming the resistance2012

    • Author(s)
      Isoyama S, Dan S, Nishimura Y, Nakamura N, Kajiwara G, Seki M, Irimura T, Yamori T
    • Journal Title

      Cancer Sci

      Volume: 103(11) Pages: 1955-1960

  • [Journal Article] Development of an immunohistochemical protein quantification system in conjunction with tissue microarray technology for identifying predictive biomarkers for phosphatidylinositol 3-kinase inhibitors2012

    • Author(s)
      Isoyama S, Yoshimi H, Dan S, Okamura M, Seki M, Irimura T, Yamori T
    • Journal Title

      Biol Pharm Bull

      Volume: 35(9) Pages: 1607-1613

  • [Journal Article] Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo2012

    • Author(s)
      Sugiura D, Denda-Nagai K, Takashima M, Murakami R, Nagai S, Takeda K, Irimura T
    • Journal Title

      PLoS One

      Volume: 7(9) Pages: e44770

  • [Journal Article] Cytokine Secretion from Human Monocytes Potentiated by P-Selectin-Mediated Cell Adhesion2012

    • Author(s)
      Suzuki J, Hamada E, Shodai T, Kamoshida G, Kudo S, Itoh S, Koike J, Nagata K, Irimura T, Tsuji T
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 160(2) Pages: 152-160

  • [Journal Article] Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma2011

    • Author(s)
      Kamiyama S, Ichimiya T, Ikehara Y, Takase T, Fujimoto I, Suda T, Nakamori S, Nakamura M, Nakayama F, Irimura T, Nakanishi H, Watanabe M, Narimatsu H, Nishihara S
    • Journal Title

      Glycobiology

      Volume: 21(2) Pages: 235-246

  • [Journal Article] Involvement of viral envelope GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin2011

    • Author(s)
      Usami K, Matsuno K, Igarashi M, Denda-Nagai K, Takada A, Irimura T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 407(1) Pages: 74-78

  • [Journal Article] Early activation and interferon-γproduction of tumor-infiltrating mature CD27 high natural killer cells2011

    • Author(s)
      Hayakawa Y, Sato-Matsushita M, Takeda K, Iwakura Y, Tahara H, Irimura T
    • Journal Title

      Cancer Sci

      Volume: 102(11) Pages: 1967-1971

  • [Journal Article] Asialoglycoprotein receptor promotes cancer metastasis by activating the EGFR-ERK pathway2011

    • Author(s)
      Ueno S, Mojic M, Ohashi Y, Higashi N, Hayakawa Y, Irimura T
    • Journal Title

      Cancer Res

      Volume: 71(20) Pages: 6419-6427

  • [Journal Article] Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b)2010

    • Author(s)
      Denda-Nagai K, Aida S, Saba K, Suzuki K, Moriyama S, Oo-Puthinan S, Tuiji M, Morikawa A, Kumamoto Y, Sugiura D, Kudo A, Akimoto Y, Kawakami H, Bovin NV, Irimura T
    • Journal Title

      J Biol Chem

      Volume: 285(25) Pages: 19193-19204

  • [Journal Article] Organ microenvironment plays significant roles through Fas ligand in vaccine-induced CD4 T cell dependent suppression of tumor growth at the orthotopic site2010

    • Author(s)
      Sugiura D, Denda-Nagai K, Takeda K, Irimura T
    • Journal Title

      Cancer Sci

      Volume: 101(9) Pages: 1965-1969

  • [Journal Article] Mucin 21/epiglycanin modulates cell adhesion2010

    • Author(s)
      Yi Y, Kamata-Sakurai M, Denda-Nagai K, Itoh T, Okada K, Ishii-Schrade K, Iguchi A, Sugiura D, Irimura T
    • Journal Title

      J Biol Chem

      Volume: 285(28) Pages: 21233-21240

  • [Journal Article] Loss of UDP-GalNAc : Polypeptide N-acetylgalactosaminyltransferase3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis2010

    • Author(s)
      Kato K, Takeuchi H, Kanoh A, Miyahara N, Nemoto-Sasaki Y, Morimoto-Tomita M, Matsubara A, Ohashi Y, Waki M, Usami K, Mandel U, Clausen H, Higashi N, Irimura T
    • Journal Title

      Glycoconj J

      Volume: 27 Pages: 267-276

  • [Journal Article] Wisteria floribunda agglutinin-positive mucin 1 is a sensitive biliary marker for human cholangiocarcinoma2010

    • Author(s)
      Matsuda A, Kuno A, Kawamoto T, Matsuzaki H, Irimura T, Ikehara Y, Zen Y, Nakanuma Y, Yamamoto M, Ohkohchi N, Shoda J, Hirabayashi J, Narimatsu H
    • Journal Title

      Hepatology

      Volume: 52(1) Pages: 174-182

  • [Journal Article] Different potential of C-type lectin-mediated entry between Marburg virus strains2010

    • Author(s)
      Matsuno K, Kishida N, Usami K, Igarashi M, Yoshida R, Nakayama E, Shimojima M, Feldmann H, Irimura T, Kawaoka Y, Takada
    • Journal Title

      J Virol

      Volume: 84(10) Pages: 5140-5147

  • [Journal Article] Macrophage receptors for influenza A virus : role of the macrophage galactose-type lectin and mannose receptor in viral entry2010

    • Author(s)
      Upham JP, Pickett D, Irimura T, Anders EM, Reading PC
    • Journal Title

      J Virol

      Volume: 84(8) Pages: 3730-3737

  • [Journal Article] C-type lectins do not act as functional receptors for filovirus entry into cells2010

    • Author(s)
      Matsuno K, Nakayama E, Noyori O, Marzi A, Ebihara H, Irimura T, Feldmann H, Takada A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 403(1) Pages: 144-148

  • [Presentation] Roles of heparanase expression in local and systemic inflammation2012

    • Author(s)
      Shida H, Sue M, Komatsu N, Waki M, Nishimura Y, Nakajima M, Higashi N, Irimura T
    • Organizer
      International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
    • Place of Presentation
      Ito Memorial Hall, The University of Tokyo, Tokyo(11/30 P)
    • Year and Date
      20121130-1201
  • [Presentation] MUC1 glycoforms have impact on protective immunity against MUC1-expressing tumor cells through the function of antigen presenting cells bearing MGL1/MGL22012

    • Author(s)
      Kimura A, Denda-Nagai K, Irimura T
    • Organizer
      International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
    • Place of Presentation
      Ito Memorial Hall, The University of Tokyo, Tokyo(11/30)
    • Year and Date
      20121130-1201
  • [Presentation] IL-17-producing NK1.1+ CD27+γδT cells promote tumor malignant progression by inducing inflammatory microenvironment2012

    • Author(s)
      Kimura Y, Sato-Matsushita M, Tahara H, Irimura T, Hayakawa Y
    • Organizer
      International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
    • Place of Presentation
      Ito Memorial Hall, The University of Tokyo, Tokyo(11/30)
    • Year and Date
      20121130-1201
  • [Presentation] Bioluminescent imaging of inflammatory tissue microenvironment in 4T1 breast cancer model2012

    • Author(s)
      Takahashi K, Irimura T, Hayakawa Y
    • Organizer
      International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
    • Place of Presentation
      Ito Memorial Hall, The University of Tokyo, Tokyo(11/30)
    • Year and Date
      20121130-1201
  • [Presentation] Characterization of gene expression profiles of early or late progressor cancer cells in inflammation-associated malignant progression model2012

    • Author(s)
      Nagai N, Tsunekawa N, Kimura Y, Irimura T, Hayakawa Y
    • Organizer
      International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
    • Place of Presentation
      Ito Memorial Hall, The University of Tokyo, Tokyo
    • Year and Date
      20121130-1201
  • [Presentation] Bioluminescent imaging of inflammatory tissue microenvironment in 4T1 breast cancer model2012

    • Author(s)
      Takahashi K, Irimura T, Hayakawa Y
    • Organizer
      International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
    • Place of Presentation
      Ito Memorial Hall, The University of Tokyo, Tokyo
    • Year and Date
      20121130-1201
  • [Presentation] Dermal dendritic cells expressing MGL2 skew the immune response toward Th2 in contact hypersensitivity2012

    • Author(s)
      Denda-Nagai K, Murakami R, Hashimoto S, Nagai S, Irimura T
    • Organizer
      The 12th International Symposium on Dendritic Cells
    • Place of Presentation
      Daegu, Korea(10/11)
    • Year and Date
      20121007-11
  • [Presentation] Esophageal squamous carcinoma and normal squamous epithelia express differentially glycosylated mucin 212012

    • Author(s)
      Tian Y, Denda-Nagai K, Kamata-Sakurai M, Nakamori S, Irimura T
    • Organizer
      14th International Biennial Conference on Metastasis Research 2012
    • Place of Presentation
      Brisbane Convention and Exhibition Centre, Cnr Merivale and Glenelg Streets, South Bank, Brisbane, Queensland, Australia(9/3, P)
    • Year and Date
      20120902-05
  • [Presentation] IL-17-producing NK1.1–CD27–gd T cells promote tumor malignant progression by inducing inflammatory microenvironment2012

    • Author(s)
      Kimura Y, Sato-Matsushita M, Tahara H, Irimura T, Hayakawa Y
    • Organizer
      20th International Symposium on Molecular Cell Biology of Macrophages 2012
    • Place of Presentation
      Sanjo Conference Hall, The University of Tokyo
    • Year and Date
      20120615-16
  • [Presentation] IL-10 induction in colonic macrophages by commensal bacteria is dependent on MGL1 and mediated by the Syk-CARD9 pathway2012

    • Author(s)
      Denda-Nagai K, Kurashina R, Hara, Naoki Yoshida H, Irimura T
    • Organizer
      20 th International Symposium on Molecular Cell Biology of Macrophages 2012
    • Place of Presentation
      Sanjo Conference Hall, The University of Tokyo(6/15)
    • Year and Date
      20120615-16
  • [Presentation] A Unique dermal dendritic cell subset expressing macrophage galactose-type C-type lectin 2 (MGL2/CD301b)2012

    • Author(s)
      Murakami R, Denda-Nagai K, Hashimoto S, Irimura T
    • Organizer
      Program for Young Researcher Symposium in Europe, supported by Graduate School of Pharmaceutical Sciences, U-Tokyo
    • Place of Presentation
      University of Oxford, UK; University of Bonn, Germany(6/8, 6/11)
    • Year and Date
      20120606-14
  • [Presentation] Glycosylation of Ebola viral envelope glycoproteins : regulation and roles in the infection2012

    • Author(s)
      Fujihira H, Usami K, Denda-Nagai K, Yamada K, Matsuno K, Shinohara Y, Takada A, Kakehi K, Irimura T
    • Organizer
      Program for Young Researcher Symposium in Europe supported by Graduate School of Pharmaceutical Sciences
    • Place of Presentation
      U-Tokyo(6/7,11, P)
    • Year and Date
      20120606-14
  • [Presentation] Asialoglycoprotein Receptor Promotes Lung Metastasis by Activating the EGFR-ERK Pathway2011

    • Author(s)
      Irimura T, Ueno S, Mojic M, Ohashi Y, Higashi N, Hyakawa Y
    • Organizer
      2011 Annual Conference of the Society for Glycobiology
    • Place of Presentation
      The Westin Seattle, WA, USA(11/11)
    • Year and Date
      20111109-12
  • [Presentation] Mucin 21/epiglycanin as a potential marker and a determinant of malignant behavior of cancer cells."Mucins in health and disease2011

    • Author(s)
      Irimura T
    • Organizer
      11th International Workshop Carcinoma-associated Mucins
    • Place of Presentation
      Robinson College, Cambridge, UK(7/13)
    • Year and Date
      20110709-13
  • [Presentation] NKG2A and NKG2C bindα2, 3-sialyated glycans and sulphated glycans."Mucins in health and disease2011

    • Author(s)
      Xin X, Irimura T
    • Organizer
      11th International Workshop Carcinoma-associated Mucins
    • Place of Presentation
      Robinson College, Cambridge, UK(7/9-13)
    • Year and Date
      20110709-13
  • [Presentation] Altered resolution of peritoneal inflammation in MMP-9-deficient mice2011

    • Author(s)
      Kolaczkowska E, Higashi N, Nishimura Y, Nakajima M, Irimura T, Opdenakker G
    • Organizer
      10th World Congress on Inflammation (WCI2011)
    • Place of Presentation
      Palais des Congres, Paris(6/27, P)
    • Year and Date
      20110625-29
  • [Presentation] Strain-dependent glycosylation of Ebola viral envelope glycoproteins determines their infectivity, note html formatting may not appear correctly2010

    • Author(s)
      Fujihira H, Usami K, Denda-Nagai K, Irimura T
    • Organizer
      2010 Annual Conference of the Society for Glycobiology
    • Place of Presentation
      Tradewinds Island Grand Resort, FL, USA(11/10)
    • Year and Date
      20101107-10
  • [Presentation]2010

    • Author(s)
      Denda-Nagai K, Irimura T
    • Organizer
      2010 Annual Conference of the Society for Glycobiology
    • Place of Presentation
      Tradewinds Island Grand Resort, FL, USA(11/8)
    • Year and Date
      20101107-10
  • [Presentation] Distribution and function of macrophage galactose-type C-type lectin 2(MGL2/CD301b)2010

    • Author(s)
      Denda-Nagai K, Murakami R, Irimura T
    • Organizer
      11^<th> International Symposium on Dendritic Cells in Fundamental and Clinical Immunology
    • Place of Presentation
      Convention Centre, Lugano, Switzerland(9/28)
    • Year and Date
      20100926-30
  • [Presentation] Regulated expression of heparanase in neutrophil extravasation2010

    • Author(s)
      Sue M, Higashi N, Nishimura Y, Nakajima M, Irimura T
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      The Kobe Convention Center Complex, Kobe, Japan(8/24)
    • Year and Date
      20100822-27
  • [Presentation] Roles of macrophage galactose-type C-type lectin 2(MGL2/CD301b)in the immune response2010

    • Author(s)
      Denda-Nagai K, Irimura T
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      The Kobe Convention Center Complex, Kobe, Japan(8/24)
    • Year and Date
      20100822-27
  • [Presentation] Heparanase regulates immune cell functions2010

    • Author(s)
      Higashi N, Waki M, Sue M, Kogane Y, Nishimura Y, Nakajima M, Irimura T
    • Organizer
      25th International Carbohydrate Symposium (ICS2010)
    • Place of Presentation
      Makuhari Messe, Chiba(8/5)
    • Year and Date
      20100801-06
  • [Presentation] Bresalier RS. Galectin-3 polymorphisms and response of human breast and colon cancer cells to apoptotic stimuli2010

    • Author(s)
      Ueno S, San YJ, Mazurek N, Byrd JC, Irimura T, Bresalier RS
    • Organizer
      8th Joint Conference of the AACR and JCA"Cancer Genomics, Epigenomics, and The Development of Novel Therapeutics
    • Place of Presentation
      Hilton Waikoloa Village, Hawaii, USA(2/6)
    • Year and Date
      20100205-09
  • [Presentation] Effect of MUC1 plasmid DNA and BM-DCs vaccination in an experimental colon carcinogenesis in MUC1 transgenic mice2010

    • Author(s)
      Murwanti R, Sugiura D, Denda-Nagai K, Kamata-Sakurai M, Irimura T
    • Organizer
      8th Joint Conference of the AACR and JCA"Cancer Genomics, Epigenomics, and The Development of Novel Therapeutics
    • Place of Presentation
      Hilton Waikoloa Village, Hawaii, USA(2/6)
    • Year and Date
      20100205-09

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Published: 2015-07-16  

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