2010 Fiscal Year Final Research Report
Molecular design and chemical genetic approach of bio-probe for anti-angiogenic therapy
| Project/Area Number |
21390033
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUDA Kensuke 岐阜薬科大学, 薬学部, 講師 (00311796)
UEDA Satoshi 岐阜薬科大学, 薬学部, 助教 (50453056)
HARA Hideaki 岐阜薬科大学, 薬学部, 教授 (20381717)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 医薬分子設計 / 血管新生阻害剤 / がん / HIF-1 / VEGF / 構造活性相関 |
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| Research Abstract |
Novel angiogenesis inhibitors were developed based on natural product chemistry-based approach using Brazilian green propolis and SAR study of arylidene thiazolidinedione(TZD) analogs library. They inhibited in vitro and in vivo angiogenesis significantly without cytotoxicity through reducing HIF-1-VEGF signaling pathway. They are promising candidates as nontoxic and selective anti-angiogenesis agents applicable to inhibit tumor and retinal angiogenesis. Now we are investigating their target protein for angiogenesis inhibition.
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