2011 Fiscal Year Final Research Report
Effects of nanomaterial exposure on cranial nerve system of offspring
| Project/Area Number |
21390037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TAKEDA Ken 東京理科大学, 薬学部・薬学科, 教授 (80054013)
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| Co-Investigator(Renkei-kenkyūsha) |
TACHIBANA Ken 東京理科大学, 薬学部・薬学科, 助教 (10400540)
YANAGITA Shinya 東京理科大学, 理工学部教養, 助教 (80461755)
SHINKAI Yusuke 東京理科大学, 薬学部, PD (80459734)
SUZUKI Kenichro 東京理科大学, 総合研究機構, PD (30548384)
UMEZAWA Masakazu 東京理科大学, 総合研究機構, PD (60615277)
SUGAMATA Masao 栃木臨床病理研究所, 所長 (50049863)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 環境衛生学 |
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| Research Abstract |
The present study showed the effects of maternal exposure to nanomaterials on the development of cranial nerve system of offspring, using electron microscopic analysis, histological analysis, neurochemical(monoamine) analysis as well as gene expression analysis. The results indicated that exposure of pregnant mice to nanomaterial frequently used in nanotechnology induced alterations of microstructures, monoamine and its metabolism in the brain of offspring during the developmental period. Gene expression analysis using microarray showed an important clue of the mechanisms underlying the effects of maternal exposure to nanomaterials on the brain development.
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[Journal Article] In utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice2010
Author(s)
Suzuki, T., Oshio, S., Iwata, M., Saburi, H., Odagiri, T., Udagawa, T., Sugawara, I., Umezawa, M., Takeda, K
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Journal Title
Part. Fibre Toxicol.
Volume: 7
Pages: 7
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[Journal Article] Maternal exposure to nanoparticulate titanium dioxide during the perinatal period alters gene expression related to brain development in the mice2009
Author(s)
Shimizu, M., Tainaka, H., Oba, T., Mizuo, K., Umezawa, M., Takeda, K
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Journal Title
Part. Fibre Toxicol.
Volume: 6
Pages: 20
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[Journal Article] Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems2009
Author(s)
Takeda, K., Suzuki, K., Ishihara, A., Kubo-Irie, M., Fujimoto, R., Tabata, M., Oshio, S., Nihei, Y., Ihara, T., Sugamata M
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Journal Title
J. Health Sci.
Volume: 55(1)
Pages: 95-102
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[Journal Article] Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice2009
Author(s)
Yokota, S., Mizuo, K., Moriya, N., Oshio, S., Sugawara, I., Takeda, K
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Journal Title
Neurosci. Lett.
Volume: 449(1)
Pages: 38-41
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[Presentation]2012
Author(s)
立花研, 高柳皓平, 秋本純芽, 新海雄介, 武田健
Organizer
日本薬学会第132年会
Year and Date
2012-03-30
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[Presentation] Titanium dioxide nanoparticles trans-ferred from pregnant mice to their offspring affect the genital and cranial nerve systems2009
Author(s)
Takeda K, Suzuki K, Ishihara A, Kubo-Irie M, Fujimoto R, Tabata M, Oshio S, Nihei N, Ihara T, Sugamata M
Organizer
PPTOXII, a CCT Meeting of Society of Toxicology
Place of Presentation
Miami Beach, Florida, USA
Year and Date
20091200
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