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2011 Fiscal Year Final Research Report

Assessment of in vivo mutagenicity and trans-generational effect of compounds contained in suspended particulate matter in urban air

Research Project

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Project/Area Number 21390038
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

AOKI Yasunobu  独立行政法人国立環境研究所, 環境リスク研究センター, 副センター長 (20159297)

Co-Investigator(Kenkyū-buntansha) NOUMI Takehiko  国立医薬品食品衛生研究所, 変異遺伝部, 部長 (30150890)
KAGEYAMA Shiho  郡山女子大学, 家政学部, 講師 (00514316)
MATSUMOTO Michi  独立行政法人国立環境研究所, 環境リスク研究センター, 主任研究員 (60132867)
NAKAJIMA Daisuke  独立行政法人国立環境研究所, 環境リスク研究センター, 主任研究員 (10281411)
Project Period (FY) 2009 – 2011
Keywords環境系薬学
Research Abstract

We evaluated mutagenesis induced in the target organs, such as the lung, by exposure of total suspended particulate matter(TSP) in ambient air using a model transgenic rodent for detecting in mutations, named gpt delta mouse. Consequently, in vivo mutagenicity of TSP extract obtained in Tsukuba City was estimated as 0.76 x 10^<-5>/mg. Compounds causing in vivo mutagenisis in Tar have not been identified, but several observations suggest that any potent mutagens other than polycyclic aromatic hydrocarbons exist in ambient air.

  • Research Products

    (19 results)

All 2012 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (14 results) Book (1 results)

  • [Journal Article] Estimation of daily inhalation rate in preschool children using a tri-axial accelerometer : a pilot study2011

    • Author(s)
      Kawahara J, Tanaka S, Tanaka C, Aoki Y, Yonemoto J
    • Journal Title

      Sci Total Environ

      Volume: 409 Pages: 3037-3077

    • Peer Reviewed
  • [Journal Article] Evaluation of the in vivo mutagenicity of nickel subsulfide in the lung of F344 gpt delta transgenic rats exposed by intratracheal instillation : A collaborative study for the gpt delta transgenic rat mutation assay2011

    • Author(s)
      Kamigaito T, Noguchi T, Narumi K, Takashima R, Hamada S, Sanada H, Hasuko M, Hayashi H, Masumura K, Nohmi T
    • Journal Title

      Genes En viron

      Volume: 34 Pages: 34-44

    • Peer Reviewed
  • [Journal Article] Evaluation of in vivo mutagenicity by 2, 4-diaminotoluene and 2, 6-diaminotoluene in liver of F344 gpt delta transgenic rat dosed for 28 days : a collaborative study of the gpt delta transgenic rat mutation assay2011

    • Author(s)
      Sui H, Ohta R, Shiragiku T, Akahori A, Suzuki K, Nakajima M, Hayashi H, Masumura K, Nohmi T
    • Journal Title

      Genes Environ

      Volume: 34 Pages: 25-33

    • Peer Reviewed
  • [Journal Article] Estimation of the respiratory ventilation rate of preschool children in daily life using accelerometers2011

    • Author(s)
      Kawahara J, Tanaka S, Tanaka C, Aoki Y, Yonemoto J
    • Journal Title

      J. Air Waste Manag. Assoc

      Volume: 61 Pages: 46-54

    • Peer Reviewed
  • [Presentation] Comparative study on the utilities of animal experimental data for risk assessment of inhalation exposure of chemicals2012

    • Author(s)
      Aoki Y, Matsumoto Y, Matsumoto M
    • Organizer
      51st Annual Meeting, Society of Toxicology
    • Place of Presentation
      Mosconw Convention Center(San Francisco)
    • Year and Date
      2012-03-12
  • [Presentation] Health risk assessemnt of air pollutants : Air pollutant genotoxicity and its enhancement on suppression of phase II drug-metabolizing enzymes2011

    • Author(s)
      Aoki Y
    • Organizer
      International Symposium on Genotoxic and Carcinogenicity Thresholds
    • Place of Presentation
      一橋記念講堂(東京都)
    • Year and Date
      2011-11-23
  • [Presentation] 大気汚染物質によるgpt deltaマウス肺中の突然変異とヒト肺がん組織中p53遺伝子の突然変異の比較2011

    • Author(s)
      青木康展,松本理,能美健彦
    • Organizer
      日本環境変異原学会第40回大会
    • Place of Presentation
      一橋記念講堂(東京都)
    • Year and Date
      2011-11-21
  • [Presentation] 遺伝子発現プロファイルと分子ネットワークによる都市大気成分の毒性寄与予測手法の開発2011

    • Author(s)
      佐藤陽美,中島大介,影山志保,後藤純雄,松下秀鶴,渡辺徹志,青木康展
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      グランシップ(静岡県)
    • Year and Date
      2011-03-30
  • [Presentation] In vivo bioassays for assessing the total environmental risk2011

    • Author(s)
      Aoki Y
    • Organizer
      Environmental Health 2011
    • Place of Presentation
      Bahia Othon Palace Hotel(Salvador, Brasil)
    • Year and Date
      2011-02-09
  • [Presentation] In vivo mutagenicity of ambient air in the lungs of gpt delta transgenic mice ; A case study in Tsukuba city, Japan2010

    • Author(s)
      Sato H, Nakajima D, Kageyama S, Sakashita Y, Yanagisawa R, Masumura K, Nohmi T, Aoki Y
    • Organizer
      2^<nd> Asian Conf. Environ. Mutagens
    • Place of Presentation
      Dusit Thani Hotel(Pattaya, Thailand)
    • Year and Date
      2010-12-16
  • [Presentation] 日本人幼児の1日肺換気量2010

    • Author(s)
      河原純子,田中千晶,田中茂穂,青木康展,米元純三
    • Organizer
      日本リスク研究学会第23回年次大会
    • Place of Presentation
      明治大学駿河台キャンパス(東京都)
    • Year and Date
      2010-11-28
  • [Presentation] 大気中の発がん物質のリスク評価-疫学研究データと動物実験データに基づく評価値の比較-2010

    • Author(s)
      松本理,青木康展
    • Organizer
      日本環境変異原学会第39回大会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2010-11-17
  • [Presentation] 大気中の粒子状物質抽出物がgpt deltaマウス肺中に示す変異原性; 2009年つくば市内, 1989年バンコク市内の試料について2010

    • Author(s)
      青木康展,佐藤陽美,中島大介,影山志保,阪下由香利,柳澤利枝,後藤純雄,松下秀鶴,増村健一,能美健彦
    • Organizer
      日本環境変異原学会第39回大会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2010-11-17
  • [Presentation] ディーゼルナノ粒子長期曝露によりgpt deltaマウス肺・肝臓に誘導される突然変異2010

    • Author(s)
      佐藤陽美,阪下由香利,増村健一,古山昭子,平野靖史郎,能美健彦,青木康展
    • Organizer
      日本環境変異原学会第39回大会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2010-11-17
  • [Presentation] 国内5地点で採取した都市大気浮遊粉じんの変異原性2010

    • Author(s)
      影山志保,稲葉洋平,佐藤陽美,松本理,青木康展,嵐谷奎一,矢島博文,中島大介,後藤純雄
    • Organizer
      第16回バイオアッセイ研究会・日本環境毒性学会合同研究発表会
    • Place of Presentation
      つくば研究支援センター(茨城県)
    • Year and Date
      2010-09-02
  • [Presentation] Assessment of in vivo mutagenesis induced by environmental chemicals using transgenic animals for detecting mutagens2009

    • Author(s)
      Aoki Y
    • Organizer
      2nd International Conference on Environmental Health Science
    • Place of Presentation
      Korea Institute of Science and Technology(Seoul, Korea)
    • Year and Date
      2009-10-30
  • [Presentation] In vivo mutagenesis induced by the air pollutants in the testis of gpt delta transgenic mice2009

    • Author(s)
      Aoki Y, Hashimoto AH, Amanuma K, Matsumoto M, Masumura K, Nohmi T
    • Organizer
      21st Cent. Adv. Mol. Toxicol. Environ. Chem. Pathog. Dis
    • Place of Presentation
      東京大学医学部鉄門講堂(東京都)
    • Year and Date
      2009-10-26
  • [Presentation] Enhanced in vivo mutations in the lung of phase II enzyme-suppressed mice2009

    • Author(s)
      Aoki Y
    • Organizer
      X International Conference on Environmental Mutagens
    • Place of Presentation
      Congress Center(Firenze, Italy)
    • Year and Date
      2009-08-22
  • [Book] Potency of air pollutants at DNA adduct formation and assessment by in vivo mutagenesis. In DNA adduct formation, detection and mutagenesis2010

    • Author(s)
      Aoki Y, Hashimoto AH, Amanuma K, Matsumoto M
    • Total Pages
      143-153
    • Publisher
      Nova Science Publishers Inc

URL: 

Published: 2013-07-31  

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