2011 Fiscal Year Final Research Report
Clarification and evaluation of regulation mechanism of uric acid
| Project/Area Number |
21390044
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAMAI Ikumi 金沢大学, 薬学系, 教授 (20155237)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRASAKA Yoshiyuki 金沢大学, 薬学系, 助教 (60453833)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 尿酸 / トランスポーター / 高尿酸血症 / 腎臓 / 消化管 / 尿酸値変動 |
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| Research Abstract |
Transporter molecule that control renal handling of uric acid and effect of uricosuric-and anti-uricosuric drugs were analyzed using in vitro and in vivo model. OAT2 was newly found as the uric acid transporter in kidney. As the animal model, uric transporters expressed in rats were characterized and found to be useful as the model of uric acid disposition. In addition, as the extra-renal elimination pathways of uric acid, intestinal secretion was found to be very important and the BCRP transporter was found to be responsible for that process. Furthermore, for in vivo analysis in human, the method for the synthesis of PET probe of uric acid was succeeded. It was preliminarily applied in PET analysis in rats. All these studies related to the mechanism and evaluation method of uric acid disposition is useful for future development of drugs that can control serum uric acid level and physiological and pathological significance of uric acid.
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Research Products
(41 results)
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[Journal Article] Synthesis of[^<11> C] uric acid, using[^<11> C] phosgene, as a possible biomarker in PET imaging for diagnosis of gout2012
Author(s)
Yashio K., Katayama Y., Takashima T., Ishiguro N., Doi H, Suzuki M., Wada Y., Tamai I., Watanabe Y.
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Journal Title
Bioorg Med Chem Lett
Volume: 22(1)
Pages: 115-9
DOI
Peer Reviewed
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