Bone marrow cell abnormality and diabetic complications

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390054
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Sapporo Medical University
• Principal Investigator: FUJIMIYA Mineko 札幌医科大学, 医学部, 教授 (10199359)
• Project Period (FY): 2009 – 2011
• Keywords: 細胞分化 / 組織形成

Research Abstract

We successfully demonstrated that diabetic complications are derived from abnormality in bone marrow stem cells, and this finding leads the therapeutic strategies for diabetic complications by replacement of bone marrow niche.

Research Products

• [Journal Article] Bone Marrow Stem Cell Abnormality and Diabetic Complications (2012)
  • Author(s): Fujimiya M, Nagaishi K, Yamashita T, Ataka K.
  • Journal Title: Anat Rec Volume: (in press)
  • DOI: doi:10.1002/ar.22445
  • Peer Reviewed
• [Journal Article] Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy (2012)
  • Author(s): Yamashita T, Fujimiya M, Nagaishi K, Ataka K, Tanaka M, Yoshida H, Tsuchihashi K, Shimamoto K, Miura T.
  • Journal Title: FASEB J Volume: 26 Pages: 1559-68
  • URL: http://www.fasebj.org/content/26/4/1559.long
  • Peer Reviewed
• [Journal Article] Metallothionein deficiency in the injured peripheral nerves of complex regional pain syndrome as revealed by proteomics (2012)
  • Author(s): Oki G, Wada T, Iba K, Aiki H, Sasaki K, Imai S, Sohma H, Matsumoto K, Yamaguchi M, Fujimiya M, Yamashita T, Kokai Y.
  • Journal Title: Pain Volume: 153 Pages: 532-9
  • Peer Reviewed
• [Journal Article] Regulation of gastroduodenal motility : acyl ghrelin, des-acyl ghrelin and obestatin and hypothalamic peptides (2012)
  • Author(s): Fujimiya M, Ataka K, Asakawa A, Chen CY, Kato I, Inui A.
  • Journal Title: Digestion Volume: 85 Pages: 90-4
  • URL: http://content.karger.com/ProdukteDB/produkte.asp?id=doi%3A10.1159%2F000334654
  • Peer Reviewed
• [Journal Article] Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat (2011)
  • Author(s): Tanaka H, Arimura Y, Yabana T, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Sasaki Y, Fujimiya M, Imai K, Shinomura Y.
  • Journal Title: J Gastroenterol Volume: 46 Pages: 143-52
  • URL: http://www.springerlink.com/content/737w51v35p3633r5/?MUD=MP
  • Peer Reviewed
• [Journal Article] Transfer of Bone Marrow Progenitors Prevents Coronary Insufficiency and Systolic Dysfunction in the Mechanical Unloaded Heart in Mice (2011)
  • Author(s): Koike M, Kojima H, Fujimiya M, Matsubayashi K, Aimi Y, Kimura H, Asai T.
  • Journal Title: J Surg Res Volume: 171 Pages: 47-57
  • Peer Reviewed
• [Journal Article] Investigation of the presence of ghrelin in the central nervous system of the rat and mouse (2011)
  • Author(s): Furness JB, Hunne B, Matsuda N, Yin L, Russo D, Kato I, Fujimiya M, Patterson M, McLeod J, Andrews ZB, Bron R.
  • Journal Title: Neuroscience Volume: 193 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility (2011)
  • Author(s): Fujimiya M, Ataka K, Asakawa A, Chen CY, Kato I, Inui A.
  • Journal Title: Peptides Volume: 32 Pages: 2348-51
  • Peer Reviewed
• [Journal Article] Chronic foot-shock stress potentiates the influx of bone marrow-derived microglia into hippocampus (2010)
  • Author(s): Brevet M, Kojima H, Asakawa A, Atsuchi K, Ushikai M, Ataka K, Inui A, Kimura H, Sevestre H, Fujimiya M.
  • Journal Title: J Neurosci Res Volume: 88 Pages: 1890-1897
  • URL: http://onlinelibrary.wiley.com/doi/10.1002/jnr.22362/abstract;jsessionid=B449EE6613C342DDEABFF776B96FC731.d01t02?systemMessage=Wiley+Online+Library+will+be+disrupted+on+9+June+from+10%3A00-12%3A00+BST+%2805%3A00-07%3A00+EDT%29+for+essential+maintenance
  • Peer Reviewed
• [Journal Article] Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3 (2010)
  • Author(s): Asakawa A, Fujimiya M, Niijima A, Fujino K, Kodama N, Sato Y, Kato I, Nanba H, Laviano A, Meguid MM, Inui A.
  • Journal Title: Psychoneuroendocrinology Volume: 35 Pages: 1178-1186
  • Peer Reviewed
• [Journal Article] Ghrelin, des-acyl ghrelin, and obestatin : regulatory roles on the gastrointestinal motility (2010)
  • Author(s): Fujimiya M, Asakawa A, Ataka K, Chen CY, Kato I, Inui A.
  • Journal Title: Int J Pept Volume: 2010
  • URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915652/?tool=pubmed
  • Peer Reviewed
• [Presentation] 糖尿病でおこる骨髄幹細胞異常 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第1回細胞再生医療研究会
  • Place of Presentation: 神戸
  • Year and Date: 2011-07-31
• [Presentation] 糖尿病合併症の原因となる骨髄幹細胞異常 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第67回日本顕微鏡学会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-16
• [Presentation] 骨髄幹細胞を標的にした糖尿病合併症の治療戦略 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第35回広島整形外科先端医学セミナー
  • Place of Presentation: 広島
  • Year and Date: 2010-11-17
• [Presentation] 骨髄由来ミクログリアと脳腸相関 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第42回消化管Motility研究会
  • Place of Presentation: 神戸
  • Year and Date: 2010-07-21
• [Presentation] 糖尿病合併症の原因となる骨髄幹細胞 (2010)
  • Author(s): 藤宮峯子
  • Organizer: 第115回日本解剖学会
  • Place of Presentation: 岩手
  • Year and Date: 2010-03-28
• [Patent(Industrial Property Rights)] Replacement of bone marrow niche cells for treatment of various diseases (2012)
  • Inventor(s): 藤宮峯子、安宅弘司、千葉弘規
  • Industrial Property Rights Holder: 札幌医科大学
  • Industrial Property Number: 米国特許、61/591, 446
  • Filing Date: 2012-01-27
  • Overseas