2011 Fiscal Year Final Research Report
Quality control mechanisms of cargo proteins in the post-Golgi trafficking
| Project/Area Number |
21390055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
WAGURI Satoshi 福島県立医科大学, 医学部, 教授 (30244908)
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| Co-Investigator(Kenkyū-buntansha) |
KAMETAKA Satoshi 福島県立医科大学, 医学部, 講師 (10303950)
YAMAMOTO Masaya 福島県立医科大学, 医学部, 准教授 (20446115)
SAWADA Naoki 福島県立医科大学, 医学部, 博士研究員 (50452644)
UEMURA Takefumi 福島県立医科大学, 医学部, 助教 (80548925)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞微細形態学 / クラスリン / 凝集体 / リソソーム分解 |
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| Research Abstract |
To elucidate physiological functions of Golgi/endosome-localized clathrin adaptors, GGAs and AP1, we performed extensive functional analysis using mammalian and drosophila model systems. We found that GGAs and AP1 are involved in the intracellular trafficking of epidermal growth factor receptor and Notch, respectively, by evading their degradations. Therefore, we propose new function of GGAs/AP1 in cell proliferation and differentiation, which would potentially be useful for developing new cancer therapy.
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[Journal Article] The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice2011
Author(s)
Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, Sato T, Date Y, Ebisawa M, Kato T, Obata Y, Fukuda S, Kawamura YI, Dohi T, Katsuno T, Yokosuka O, Waguri S, Ohno H.
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Journal Title
Gastroenterology
Volume: 141
Pages: 621-632
Peer Reviewed
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