2011 Fiscal Year Final Research Report
Clarification of properties of chloride channels, SLC26A7 and 26A9, involved in novel cytoprotective mechanism
| Project/Area Number |
21390056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | University of Toyama |
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Principal Investigator |
SAKAI Hideki 富山大学, 大学院・医学薬学研究部(薬学), 教授 (60242509)
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| Co-Investigator(Kenkyū-buntansha) |
MORII Magotoshi 鈴鹿医療科学大学, 薬学部, 教授 (60019130)
SHIMIZU Takahiro 富山大学, 大学院・医学薬学研究部(薬学), 准教授 (40353437)
FUJII Takuto 富山大学, 大学院・医学薬学研究(薬学), 助教 (50567980)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 胃酸分泌細胞 / 細胞防御 / ホメオスタシス / イオンチャネル / 塩化物イオン |
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| Research Abstract |
The gastric parietal cell secretes strong acid, but the cell is not digested by acid. Therefore, it is thought that the parietal cell possesses the sophisticated cytoprotective mechanism. So far, we found that function of a cytoprotective Cl^-channel is essential for the mechanism. In this study, we tried to clarify physiological function of two kinds of Cl^-channels, SLC26A7 and SLC26A9, in the parietal cell. We found that SLC26A7 is an essential molecule for maintaining the function of cytoprotective Cl^-channel, and that SLC26A9 is activated by acidic pH and inhibited by hyperosmolality
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[Journal Article] Syntheses, determination of the absolute stereochemistry, and evaluations at the nicotinic acetylcholine receptors of a hydroxyindolizine alkaloid from the ant Myrmicaria2009
Author(s)
Zhou D., Toyooka N., Nemoto H., Yamaguchi K., Tsuneki H., Wada T., Sasaoka T., Sakai H., Tezuka Y., Kadota S., Jones T. H., Garraffo H. M., Spande T. F. and Daly J. W.
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Journal Title
Heterocycles
Volume: 79
Pages: 565-571
Peer Reviewed
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