2011 Fiscal Year Final Research Report
Study of the regulatory mechanism of ETAR and ETBR level by receptor binding protein and the relevance between clinical significance and endothelin receptor level.
| Project/Area Number |
21390068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MIWA Soichi 北海道大学, 大学院・医学研究科, 教授 (40157706)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYA Tadashi 北海道大学, 大学院・医学研究科, 講師 (80399831)
HORINOUCHI Takahiro 北海道大学, 大学院・医学研究科, 講師 (20307771)
TERADA Koji 北海道大学, 大学院・医学研究科, 助教 (70342722)
NISHIMOTO Arata 北海道大学, 大学院・医学研究科, 助教 (90396325)
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| Project Period (FY) |
2009 – 2011
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| Keywords | エンドセリン受容体 / ユビキチン化 / 受容体結合タンパク質 / タンパク質分解 / trafficking |
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| Research Abstract |
We identified Jab1 as a C-tail binding protein of endothelin receptors (ETRs), including ET_AR and ET_BR and showed that Jab1 regulates receptor levels via ubiquitination of ETRs. We also found that ubiquitination level of ET_BR was increased upon endothelin-1 (ET-1) stimulation. Moreover, we indicated that the ubiquitination was required for ET-1-induced ET_BR internalization. Thus, we have demonstrated that ubiquitination has an important role in the regulation of trafficking of ETRs.
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[Journal Article] Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT1A receptor function in adult rats2011
Author(s)
Matsuzaki H., Izumi T., Horinouchi T., Boku S., Inoue T., Yamaguchi T., Yoshida T., Matsumoto M., Togashi H., Miwa S., Koyama T. and Yoshioka M.
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Journal Title
Psychopharmacology (Berl)
Volume: 214
Pages: 329-337
Peer Reviewed
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