2011 Fiscal Year Final Research Report
Mechanism for HMGB-or HMGB1-derived peptide-induced increase in BBB permeability
| Project/Area Number |
21390071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
RYU Katsuyaku 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40432637)
WAKE Hidenori 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60570520)
TAKAHASHI Hideo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60335627)
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| Project Period (FY) |
2009 – 2011
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| Keywords | HMGB1 / 脳血管透過性 / 脳浮腫 |
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| Research Abstract |
A representative damage-associated molecular pattern, high mobility group box-1(HMGB1), was released from neuronal nuclei to extracellular space via cytosol after ischemia or traumatic brain injury. The released HMGB1 induced contractile response in vascular endothelial cells and pericytes leading to the increased permeability of BBB. Among HMGB1-derived peptides, some had plural activities. Anti-HMGB1 monoclonal antibody inhibited the BBB permeability and inflammatory responses induced by traumatic brain injury.
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