2011 Fiscal Year Final Research Report
Activity-dependent regulation of spine morphology by RICS/PX-RICS
| Project/Area Number |
21390075
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AKIYAMA Tetsu 東京大学, 分子細胞生物学研究所, 教授 (70150745)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tsutomu 東京大学, 分子細胞生物学研究所, 講師 (30302798)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞内情報伝達 / 分子神経生物学 / 神経可塑性 |
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| Research Abstract |
Postsynaptic protein RICS is thought to serve as a link between excitatory signaling and synaptic adhesion. In this research project, we showed that, by using hippocampal neurons of RICS knockout mice, RICS functions downstream of NMDA/CaMKII signaling and upstream of Cdc42/JNK signaling. We also demonstrated that PX-RICS, a splicing variant of RICS, is localized to the spine apparatus together with its cargos(N-cadherin,β-catenin), linkers(GABARAP, 14-3-3) and motors(dynein, dynactin). These findings suggest that PX-RICS-dependent trafficking system works in dendrites and/or dendritic spines.
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Author(s)
Morishita EC, Murayama K, Kato-Murayama M, Ishizuka-Katsura Y, Tomabechi Y, Hayashi T, Terada T, Handa N, Shirouzu M, Akiyama T, Yokoyama S
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DOI
Peer Reviewed
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Journal Title
Proc Natl Acad Sci USA
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Peer Reviewed
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