2011 Fiscal Year Final Research Report
Functional redundancy and hierarchy of glycosphingolipids in the architectures and regulations of lipid rafts in vivo
| Project/Area Number |
21390076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
KOICHI Furukawa 名古屋大学, 大学院・医学系研究科, 教授 (80211530)
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| Co-Investigator(Renkei-kenkyūsha) |
JIRO Usukura 名古屋大学, 大学院・工学系研究科, 教授 (30143415)
AKIHIRO Kusumi 京都大学, 再生医科学研究所, 教授 (50169992)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ガングリオシド / ノックアウト / 炎症 / 神経変性 / ニューロン / 脂質ラフト / グリア |
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| Research Abstract |
Using various knockout mice lacking synthetic enzyme genes responsible for the synthesis of gangliosides, we analyzed abnormal phenotypes of the mutamt mice. Analysis of the changes in the composition and chemical structures of glycolipids was performed, and comparison of architectures and dynamic features of lipid rafts among those mutant mice was also done. Consequently, abnormal rafts depending on the degree of the defects of gangliosides were elucidated. Furthermore, roles of gangliosides in the regulation of signals and of complements in lipid rafts were also clarified.
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[Journal Article] Involvement of NGF in the rat model of persistent muscle pain associated with taut band2011
Author(s)
Hayashi K, Ozaki N, Kawakita K, Itoh K, Mizumura K, Furukawa K, Yasui M, Hori K, Yi SQ, Yamaguchi T, Sugiura Y
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Journal Title
J Pain.
Volume: 12(10)
Pages: 1059-1068
Peer Reviewed
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[Journal Article] C9-R95X Polymorphism in Patients with Neovascular Age-Related Macular Degeneration2011
Author(s)
Nishiguchi KM, Yasuma TR, Tomida D, Nakamura M, Ishikawa K, Kikuchi M, Ohmi Y, Niwa T, Hamajima N, Furukawa K, Terasaki H
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 53(1)
Pages: 508-12
Peer Reviewed
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[Journal Article] Impairedhippo campal long-term potentiation and failure of learning inβ1 4-N-acetylgalactosaminy l transferasegene transgenic mice.2011
Author(s)
Ikarashi K, Fujiwara H, Yamazaki Y, Goto J, Kaneko K, Kato H, Fujii S, Sasaki H, Fukumoto S, Furukawa K, Waki H, Furukawa K
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Journal Title
Glycobiology
Volume: 21(10)
Pages: 1373-81
Peer Reviewed
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[Journal Article] The neuropathic potential of anti-GM1 autoantibodies is regulated by the localglycolipid environment in mice2009
Author(s)
Greenshields KN, Halstead SK, Zitman FM, Rinaldi S, Brennan KM, O' Leary C, Chamberlain LH, Easton A, Roxburgh J, PedianiJ, Furukawa K, Furukawa K, Goodyear CS, Plomp JJ, Willison HJ
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Journal Title
J Clin Invest.
Volume: 119(3)
Pages: 595-610
Peer Reviewed
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