2011 Fiscal Year Final Research Report
Analysis of molecular mechanisms that reciprocally regulate growth and differentiation of mature hepatocytes
| Project/Area Number |
21390079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKA Kiyomasa 大阪大学, 産学連携本部, 特任准教授 (70314474)
FUKUTA Kazuhiro 大阪大学, 先端科学イノベーションセンター, 招聘准教授 (90379264)
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| Co-Investigator(Renkei-kenkyūsha) |
FUNAKOSHI Hiroshi 大阪大学, 医学系研究科, 准教授 (40273685)
MIZUNO Shinya 大阪大学, 医学系研究科, 助教 (10219644)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞内シグナル伝達 |
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| Research Abstract |
Growth and differentiated functions of mature hepatocytes are reciprocally regulated by cell density.
(1) We found that a furin-like protease activity is involved in HGF-mediated LAR activation under high-cell density conditions.
(2) Using TDO promoter-EGFP transgenic mice, we found that a conserved homologous region exists among the species. Furthermore, C/ EBP-αcan bind its site and activate promoter activity.
(3) Proline is an essential amino acid for hepatocyte growth. Proline increased accumulation of cyclin D and E proteins via newly synthesized collagen.
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[Journal Article] Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord Injury2011
Author(s)
Kitamura K, Fujiyoshi K, Yamane J, Toyota F, Hikishima K, Nomura T, Funakoshi H, Nakamura T, Aoki M, Toyama Y, Okano H, Nakamura M.
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Journal Title
PLOS one
Volume: 6
Pages: e27706
DOI
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[Journal Article] Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury2011
Author(s)
Esaki S, Kitoh J, Katsumi S, Goshima F, Kimura H, Safwat M, Yamano K, Watanabe N, Nonoguchi N, Nakamura T, Coffin RS, MiyatakeSI, Nishiyama Y, Murakami S.
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Journal Title
Gene Ther
Volume: 18
Pages: 1063-9
DOI
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