2011 Fiscal Year Final Research Report
Phys i o I og i ca I f unct i on and regu I atory mechan i sm of Fhodl and Fhod3, proteins that regulate actin filaments
| Project/Area Number |
21390084
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEYA Ryu 九州大学, 大学院・医学研究院, 講師 (50335981)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞骨格 / アクチン / formin / Fhod / 筋細胞 |
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| Research Abstract |
Fhod3, a member of formin family proteins that play pivotal roles in actin filament assembly, plays a crucial role in organization of the sarcomere(the contractile unit of myofibrils) in cultured cardiomyocytes. Indeed Fhod3-gene-deficient mice are embryonic lethal due to defective myofibrillogenesis at an early stage of heart development. Thus Fhod3 is a protein essential for cardiogenesis.
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Research Products
(52 results)
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[Journal Article] Blockade of inflammatory responses by a smallmolecule inhibitor of the Rac activator DOCK22012
Author(s)
Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saitoh N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, and Fukui Y.
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Journal Title
Chem. Biol
Volume: 19
Pages: 488-497
Peer Reviewed
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[Journal Article] and Shimada, I. Atypical membraneembedded PI(3, 4) P2 binding site on p47p"ーX PX domain revealed by NMR2012
Author(s)
Stampoulis, P., Ueda, T., Matsumoto, M., Terasawa, H., Miyano, K., Sumimoto, H.
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Journal Title
J. Biol. Chem
Volume: 287
Peer Reviewed
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[Journal Article] Selectively induced apoptosis in human neutrophils in the presence of oxidative phenoxazines, 2-amino-4, 4 a dihydryo4 a 71I-phenoxazine-3-one and 2aminophenoxazine-3-one preceded by decrease of intracellular pH, depolarization of the mitochondria and inh2011
Author(s)
Tabuchi T, Che X.-F, Hiraishi K, Adachi M, Miyano K, Sumimoto H, Tabuchi T, Miyazawa K, and Tomoda A.
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Journal Title
J. Pharmacol. Sci
Volume: 117
Pages: 139-148
Peer Reviewed
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[Journal Article] Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4mediated Rac activation2010
Author(s)
Nishida M, Suda R, Nagamatsu Y, Tanabe S, Onohara N, Nakaya M, Kanaho Y, Shibata T, Uchida K, Sumimoto H, Sato Y, Kurose H.
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 15268-15277
Peer Reviewed
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