Comprehensive analysis of the regulation of carcinogenesis through TRIM type ubiquitin ligases

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390087
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Hokkaido University
• Principal Investigator: HATAKEYAMA Shigetsugu 北海道大学, 大学院・医学研究科, 教授 (70294973)
• Co-Investigator(Renkei-kenkyūsha): OKUMURA Fumihiko 北海道大学, 大学院・医学研究科, 助教 (00507212) ; TSUKIYAMA Tadasuke 北海道大学, 大学院・・医学研究科, 助教 (20399819)
• Project Period (FY): 2009 – 2011
• Keywords: 分子腫瘍学

Research Abstract

Ubiquitination is one of the posttranslational modifications used by eukaryotic cells, and the ubiquitin-mediated proteolytic pathway plays a crucial role in the elimination of short-lived regulatory proteins. Members of the family of tripartite motif (TRIM)-containing proteins are idefined as E3 ubiquitin ligases. There are now more than 70 known TRIM proteins in humans and mice. In this study, we analyzed the relationship between TRIM proteins and cancinogenesis.

Research Products

• [Journal Article] TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and indices neuritogenesis (2012)
  • Author(s): Yaguchi, H., Okumura, F., Takahashi, H., Kano, T., Kameda, H., Uchigashima, M., Tanaka, S., Watanabe, M., Sasaki, H. and Hatakeyama, S.
  • Journal Title: J. Biol. Chem. Volume: 287 Pages: 12050-12059
  • DOI: DOI:10.1074/jbc.M111.307678
  • Peer Reviewed
• [Journal Article] TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonal stem cells (2012)
  • Author(s): Sato, T., Okumura, F., Ariga, T. and Hatakeyama, S.
  • Journal Title: J. Cell Sci. Volume: 125 Pages: 1544-1555
  • DOI: DOI:10.1242/jcs.088799
  • Peer Reviewed
• [Journal Article] TRIM32 promotes retinoic acid receptor alpha-mediated differentiation in human promyelogenous leukemic cell line HL60 (2012)
  • Author(s): Sato, T., Okumura, F., Iguchi, A., Ariga, T. and Hatakeyama, S.
  • Journal Title: Biochem. Biophys. Res.Commun. Volume: 417 Pages: 594-600
  • DOI: DOI:10.1016/j.bbamcr.2011.12.012
  • Peer Reviewed
• [Journal Article] TRIM proteins and cancer (2011)
  • Author(s): Hatakeyama, S.
  • Journal Title: Nature Rev. Cancer Volume: 11 Pages: 792-804
  • DOI: DOI:10.1038/nrc3139
  • Peer Reviewed
• [Journal Article] TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription (2011)
  • Author(s): Sato, T., Okumura, F., Kano, S., Kondo, T., Ariga, T. and Hatakeyama, S.
  • Journal Title: J.Cell Sci. Volume: 24 Pages: 3492-3502
  • DOI: DOI:10.1242/jcs.088799
  • Peer Reviewed
• [Journal Article] TRIM8 regulates Nanog via Hsp90 beta-mediated nuclear translocation of STAT3 in embryonic stem cells (2011)
  • Author(s): Okumura, F., Okumura, A.J., Matsumoto, M., Nakayama, K.I. and Hatakeyama, S.
  • Journal Title: BBA-Mol. Cell Res. Volume: 1813 Pages: 1784-1792
  • DOI: DOI:10.1016/j.bbamcr.2011.05.013
  • Peer Reviewed
• [Journal Article] TRM40 promotes neddylation of IKK gamma and is downregulated in gastrointestinal cancers (2011)
  • Author(s): Noguchi, K., Okumura, F., Takahashi, N., Kataoka, A., Kamiyama, T., Todo, S. and Hatakeyama, S.
  • Journal Title: Carcinogenesis Volume: 32 Pages: 995-1004
  • DOI: DOI:10.1093/carcin/bgr068
  • Peer Reviewed
• [Journal Article] TRIM29 negativelyregulates p53 via inhibition of Tip60 (2011)
  • Author(s): Sho, T., Tsukiyama, T., Sato, T., Kondo, T., Cheng, J., Saku, T., Asaka, M. and Hatakeyama, S.
  • Journal Title: BBA-Mol. Cell Res. Volume: 1813 Pages: 1245-1253
  • DOI: DOI:10.1016/j.bbamcr.2011.03.018
  • Peer Reviewed
• [Journal Article] MDA-9/synten ininteracts with ubiquitin via a novel ubiquitin binding motif (2011)
  • Author(s): Okumura, F., Yoshida, K., Liang, F. and Hatakeyama, S.
  • Journal Title: Mol. Cell.Biochem. Volume: 352 Pages: 163-172
  • Peer Reviewed
• [Journal Article] UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. (2011)
  • Author(s): Wu, H., Pomeroy, S.L., Ferreira, M., Teider, N., Mariani, J., Nakayama, K.I., Hatakeyama, S., Tron, V.A., Saltibus, L.F., Spyracopoulos, L. and Leng, R. P.
  • Journal Title: Nature Med. Volume: 17 Pages: 347-355
  • Peer Reviewed
• [Journal Article] Plasma gelsolin facilitates interaction between beta 2 glycoprotein I and alpha 5 beta 1 integrin (2011)
  • Author(s): Bohgaki, M., Matsumoto, M., Atsumi, T., Kondo, T., Yasuda, S., Horita, T., Nakayama, K.I., Okumura, F., *Hatakeyama, S. and Koike, T.
  • Journal Title: J. Cell. Mol. Med. Volume: 15 Pages: 141-151
  • Peer Reviewed
• [Journal Article] RNF43 interacts with NEDL1 and regulates p53-mediated transcription (2011)
  • Author(s): Shinada, K., Tsukiyama, T., Sho, T., Okumura, F., Asaka, M., Hatakeyama, S.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 404 Pages: 143-147
  • Peer Reviewed
• [Journal Article] Molecular basis for the association of human E4B U-box ubiquitin ligase with E2 conjugating enzymes UbcH5C and Ubc4 (2010)
  • Author(s): Benirschke, R. C., Thompson, J. R., Nomine, Y., Wasielewski, E., Juranic, N., Macura, S., Hatakeyama, S., Nakayama, K.I., Botuyan, M.V., Mer, G.
  • Journal Title: Structure Volume: 18 Pages: 955-965
  • Peer Reviewed
• [Journal Article] TRIM8 modulates STAT3 activity through negative regulation of PIAS3 (2010)
  • Author(s): Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K.I., Hatakeyama, S.
  • Journal Title: J. Cell Sci. Volume: 123 Pages: 2238-2245
  • Peer Reviewed
• [Journal Article] Expression of recombinant sea urchin cellulase SnEG54 using mammalian cell lines (2010)
  • Author(s): Okumura, F., Kameda, H., Ojima, T., Hatakeyama, S.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 395 Pages: 352-355
  • Peer Reviewed
• [Journal Article] Directbinding of TRAF2 and TRAF6 toTICAM-1/TRIF adaptor participates inactivation of the Toll-like receptor 3/4pathway (2010)
  • Author(s): Sasai, M., Tatematsu, M., Oshiumi, H., Funami, K., Matsumoto, M., Hatakeyama, S. and Seya, T.
  • Journal Title: Mol. Immunol. Volume: 47 Pages: 1283-1291
  • Peer Reviewed
• [Journal Article] The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt (2009)
  • Author(s): Suizu. F., Hiramuki, Y., Okumura, F., Matsuda, M., Okumura, A.J., Hirata, N., Narita, M., Kohno, T., Yokota, J., Bohgaki, M., Obuse, C., Hatakeyama, S., Obata, T. and Noguchi, M
  • Journal Title: Dev. Cell Volume: 17 Pages: 800-810
  • Peer Reviewed
• [Journal Article] TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells (2009)
  • Author(s): Kikuchi, M., Okumura, F., Tsukiyama, T., Watanabe, M., Miyajima, N., Tanaka, J., Imamura, M., Hatakeyama, S.
  • Journal Title: BBA-MCR. Volume: 1793 Pages: 1828-1836
  • Peer Reviewed
• [Journal Article] Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer (2009)
  • Author(s): Maeda, H., Miyajima, N., Kano, S., Tsukiyama, T., Okumura, F., Fukuda, S. and Hatakeyama, S.
  • Journal Title: Mol. Cancer Res. Volume: 7 Pages: 1553-1562
  • Peer Reviewed
• [Journal Article] Human synovialsarcoma proto-oncogene Syt isessential for early embryonicdevelopment through the regulation ofcell migration (2009)
  • Author(s): Kimura, T., Sakai, M., Tabu, K., Wang, L., Tsunematsu, R., Tsuda, M., Sawa, H., Nagashima, K., Nishihara, H., Hatakeyama, S., Nakayama, K., Ladanyi, M., Tanaka, S. and Nakayama, K.I
  • Journal Title: Lab. Invest. Volume: 89 Pages: 645-656
  • Peer Reviewed
• [Journal Article] Large-scale proteomic analysis of tyrosine phosphorylation induced by TCR or BCR activation reveals new signaling pathways (2009)
  • Author(s): Matsumoto, M., Oyamada, K., Takahashi, H., Sato, T., Hatakeyama, S. and Nakayama, K.I.
  • Journal Title: Proteomics Volume: 9 Pages: 3549-3563
  • Peer Reviewed
• [Journal Article] Riplet/RNF135, a RING-finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection (2009)
  • Author(s): Oshiumi, H., Matsumoto, M., Hatakeyama, S. and Seya, T.
  • Journal Title: J. Biol. Chem. Volume: 284 Pages: 807-817
  • Peer Reviewed
• [Journal Article] ZNRF1 interacts with tubulin and regulates cell morphogenesis (2009)
  • Author(s): Yoshida. K., Watanabe, M., and Hatakeyama , S.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 389 Pages: 506-511
  • Peer Reviewed
• [Journal Article] TRIM31 interacts with p52Shc and inhibits Src-induced anchorage-independent growth (2009)
  • Author(s): Watanabe, M., Tsukiyama, T. and Hatakeyama, S.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 388 Pages: 422-427
  • Peer Reviewed
• [Journal Article] Ymer acts as a multufunctional regulator in NF-kB and Fas signaling pathways
  • Author(s): Tsukiyama, T., Matsuda-Tsukiyama, M., Bohgaki, M., Terai, S., Tanaka, S. and Hatakeyama, S.:
  • Journal Title: Mol. Med. Volume: (in press)
  • Peer Reviewed
• [Presentation] Ymer functions as a multifunctional regulator in NF-kB and Fas signaling pathways. (2012)
  • Author(s): Tsukiyama T., Tsukiyama M M., bohgaki M., Tanaka S., Hatakeyama, S.
  • Organizer: the 41st meeting of the Australasian Society for immunology 2011
  • Place of Presentation: Adelaide Convention Center, Adelaide
  • Year and Date: 20121211-15
• [Presentation] TRIM proteins in inflammation and carcinogenesis. (2012)
  • Author(s): Hatakeyama, S.
  • Organizer: 2nd international symposium : Infection-related canbcers (Institute for Genetic Medicine, Hokkaido University, Research Center for Infection-associated Cancer (RCIAC))
  • Place of Presentation: Sapporo
  • Year and Date: 20120312-13
• [Presentation] 特別講演「癌化を制御するTRIMファミリーユビキチンリガーゼ」 (2012)
  • Author(s): 畠山鎮次
  • Organizer: 第21回泌尿器科分子・細胞研究会
  • Place of Presentation: 北海道大学医学部学友会館「フラテ」,札幌
  • Year and Date: 20120210-11
• [Presentation] ダイオキシン受容体内因性リガンドによる前立腺がん細胞におけるアンドロゲンレセプター発言低下と増殖抑制 (2012)
  • Author(s): 丸山覚,築山忠維,河津隆文,佐藤択矢,千葉博基,安部崇重,佐澤陽,篠原信雄,畠山鎮次,野々村克也
  • Organizer: 第21回泌尿器科分子・細胞研究会
  • Place of Presentation: 北海道大学医学部学友会館「フラテ」,札幌
  • Year and Date: 20120210-11
• [Presentation] 癌化を制御するTRIMファミリーユビキチンリガーゼ (2012)
  • Author(s): 畠山鎮次
  • Organizer: 日本実験動物技術者協会北海道支部第59回特別講演
  • Place of Presentation: 北海道大学,札幌
  • Year and Date: 2012-04-26
• [Presentation] Role of apolipoprotein B100 and oxidized low-density lipoprotein in anti beta2 glycoprotein I induced tissue factor expression on monocytes. (2011)
  • Author(s): Otomo K, Atsumi T, Fujieda Y, Nakagawa H, Amengual O, Kato M, Horita T, Tasuda S, Matsumoto M, Hatakeyama, S., Koike T.
  • Organizer: The 75th annual meeting of the American College of Rheumatology
  • Place of Presentation: Cicago, Illinois
  • Year and Date: 20111105-09
• [Presentation] RIMファミリー分子によるPPARγシグナルの制御 (2011)
  • Author(s): 渡部昌,畠山鎮次
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館,京都
  • Year and Date: 20110921-24
• [Presentation] 癌化の関与するTRIMファミリーユビキチンリガーゼ (2010)
  • Author(s): 畠山鎮次
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪国際会議場,大阪
  • Year and Date: 2010-09-24
• [Presentation] 古典的生化学手法と質量分析技術の融合によるユビキチンリガーゼの基質同定の可能性 (2010)
  • Author(s): 畠山鎮次
  • Organizer: 文部科学省科研費特定領域研究「タンパク質分解」公開シンポジウム
  • Place of Presentation: 東京ガーデンパレス,東京
  • Year and Date: 2010-08-21
• [Presentation] ユビキチンシステム関連酵素の多様性と機能 (2010)
  • Author(s): 畠山鎮次
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌コンベンションセンター,札幌
  • Year and Date: 2010-06-17
• [Book] タンパク質分解系による生体制御,「複雑化するユビキチンリガーゼの機能と多様性」 (2011)
  • Author(s): 畠山鎮次
  • Publisher: 羊土社
• [Book] PSA and Prostate Cancer (2011)
  • Author(s): Maruyama, S. , Nonomura, K, Hatakeyama, S.
  • Total Pages: 137-152
  • Publisher: Nova Science Publishers
• [Book] Handbook of Prostate Cancer Cell Research : Growth, Signalling and Survival
  • Author(s): Hatakeyama, S
  • Publisher: Nova Science Publishers (New York)
• [Remarks]
  • URL: http://www.hucc.hokudai.ac.jp/~d20505/index.html