2011 Fiscal Year Final Research Report
Study on role of membrane-type matrix metalloproteinase-1 in tumor malignancy
| Project/Area Number |
21390091
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
SATO Hiroshi 金沢大学, がん進展制御研究所, 教授 (00115239)
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| Co-Investigator(Kenkyū-buntansha) |
TAKINO Takahisa 金沢大学, がん進展制御研究所, 准教授 (40322119)
NAKADA Mitsutoshi 金沢大学, 医学系, 講師 (20334774)
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| Project Period (FY) |
2009 – 2011
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| Keywords | MT1-MMP / がん転移 / 浸潤 / 細胞外マトリックス / プロテアーゼ / シェディング |
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| Research Abstract |
We screened new substrates for MT1-MMP, which plays an important role in tumor invasion and metastasis, and analyzed pathophysiologicanl significance of it. These studies demonstrated that cleavage and shedding of membrane proteins by MT1-MMP is quite unique. For example, cleavage of serine protease inhibitor Hepatocyte Growth Factor Activator Inhibitor-1 by MT1-MMP initiates protease activation cascade, which subsequently causes tissue destruction. We named it as protease storm.
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