2011 Fiscal Year Final Research Report
MAINTENANCE OF PROTEIN HOMEOSTASIS REGULATED BY HEAT SHOCK FACTOR
| Project/Area Number |
21390095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NAKAI Akira 山口大学, 大学院・医学系研究科, 教授 (60252516)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Mitsuaki 山口大学, 大学院・医学系研究科, 講師 (80359900)
TAKH Ryousuke 山口大学, 大学院・医学系研究科, 助教 (00419558)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 熱ショック / 蛋白質 / ホメオスタシス / 転写 / フォールディング / 分解 / ポリグルタミン / マウス |
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| Research Abstract |
Cellular protein homeostasis(proteostasis) capacity, or buffering capacity of protein misfolding, is related with aging and aging-associated protein misfolding diseases. One of prominent mechanisms of the maintenance of proteostasis capacity is the heat shock response, which is regulated mainly at the level of transcription by heat shock factor(HSF). In this research project, we first demonstrate that HSF1 controls proteostasis capacity by regulating not only heat shock proteins(HSPs), which facilitate protein folding, but also non-HSP proteins with diverse function including protein degradation.
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