2011 Fiscal Year Final Research Report
Molecular Mechanisms to Regulate The Metabolism of Water and Electrolytes
| Project/Area Number |
21390096
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kochi University |
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Principal Investigator |
HONKE Koichi 高知大学, 教育研究部・医療学系, 教授 (80190263)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 代謝異常学 / 水・電解質代謝 |
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| Research Abstract |
Aiming at elucidation of molecular regulatory mechanisms underlying the reabsorption of water and electrolytes on the distal tubules and collecting ducts of the nephron, we demonstrated calcineurin is involved in the signaling pathway dictating the angiotensin II-dependent aldosteron secretion. Further, we found that deficiency of the mascurin gene causes depletion of the antidiuretic hormone(vasopressin). Finally, amounts of urine and water intake were increased when a high salt concentration of water was given to the sulfated glycolipid-deficient mice. However expression levels and membrane localizations of aquaporin and Na^+, K^+-ATPase were not deteriorated.
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