2011 Fiscal Year Final Research Report
Molecular mechanism of signal transduction by reactive oxygen species
| Project/Area Number |
21390097
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
AKAIKE Takaaki 熊本大学, 大学院・生命科学研究部, 教授 (20231798)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Shigemoto 熊本大学, 大学院・生命科学研究部, 助教 (00325333)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 活性酸素 / シグナル伝達 / 酸化ストレス / 8-nitro-cGMP / S-グアニル化 |
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| Research Abstract |
8-Nitro-cGMP is involved in reactive oxygen species-mediated signaling via protein S-guanylation. Here we identified several particular S-guanylated proteins(e. g., H-Ras etc.) occurring in cells and their involvement in various cellular signaling functions. We also revealed that endogenously produced hydrogen sulfide regulates protein S-guanylation in cells.
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[Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration2012
Author(s)
Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, and Akaike T
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Journal Title
Nature Chem Biol
Volume: (in press)
Peer Reviewed
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[Journal Article] Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreaticβ-cells2012
Author(s)
Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, and Yamagata K
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Journal Title
J Biol Chem
Volume: (in press)
Peer Reviewed
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[Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012
Author(s)
Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
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Journal Title
J Pharm Sci
Volume: (in press)
Peer Reviewed
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[Journal Article] Potential association of Helicobacter cinaedi with atrial arrhythmia and atherosclerosis2012
Author(s)
Khan S, Okamoto T, Enomoto K, Sakashita N, Oyama K, Fujii S, Sawa T, Takeya M, Ogawa H, Yamabe H, and Akaike T
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Journal Title
Microbiol Immunol
Volume: 56
Pages: 145-154
Peer Reviewed
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[Journal Article] Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice2011
Author(s)
Tokutomi Y, Kataoka K, Yamamoto E, Nakamura T, Hisato F, Nako H, Toyama K, Dong YF, Ahmed KA, Sawa T, Akaike T, and Kim-Mitsuyama S
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Journal Title
Br J Pharmacol
Volume: 162
Pages: 1884-1893
Peer Reviewed
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[Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response2010
Author(s)
Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahmed KA, Ishima Y, Motohashi H, Yamamoto M, and Akaike T
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Journal Title
J Biol Chem
Volume: 285
Pages: 23970-23984
Peer Reviewed
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[Presentation] Role of Keap1 S-guanylation in the antioxidant adaptive response in C6 glioma cells2010
Author(s)
Shigemoto Fujii, Tomohiro Sawa, Hideshi Ihara, Tomoaki Ida, Tatsuya Okamoto, Hozumi Motohashi, Masayuki Yamamoto, Takaaki Akaike
Organizer
6th International Conference on Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
Place of Presentation
Kyoto, Kyoto International Conference Center
Year and Date
20100614-18
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