Molecular analysis of leukemogenesis of adult-T cell leukemia by genomic abnormalities

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390098
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: University of Miyazaki
• Principal Investigator: MORISHITA Kazuhiro 宮崎大学, 医学部, 教授 (80260321)
• Co-Investigator(Kenkyū-buntansha): TANIWAKI Masafumi 京都府立医科大学, 医学部, 教授 (80163640) ; NAKAHATA Shingo 宮崎大学, 医学部, 助教 (80437938) ; NISHIKATA Ichiro 宮崎大学, 医学部, 助教 (50253844)
• Project Period (FY): 2009 – 2011
• Keywords: TSLC1/CADM1/IgSF4 / TCF8(ZEB1) / NDRG2 / 成人T細胞白血病(ATL) / BCL11B

Research Abstract

To elucidate the mechanism of multistep leukemogenesis of adult-T cell leukemia(ATL) after HTLV-1 infection, we performed an integrated genomic analysis of ATL using spectral karyotyping(SKY), high density SNP array, and DNA microarray. As a result, we identified three translocation breakpoint cluster regions(10p11, 14q11, and 14q32) and found TCF8(ZEB1) at chromosome 10p11, NDRG2 at 14q11, and BCL11B at 14q32 as candidate tumor suppressor genes. Using genome-wide gene expression profiles, we also identified TSLC1 as a novel cell surface marker for ATL. We demonstrated that downregulation of TCF8 with upregulation of Smad7 renders ATL cells resistance to TGFbeta and downregulation of NDRG2 is a major cause of constitutive PI3K/AKT activation, and that overexpression of TSLC1 is associated with organ infiltration of ATL cells. The majority of TCF8-deficient and TSLC1-transgenic mice developed T-lymphoma with multiple organ invasions and a wide variety of cancers including T-cell lymphoma were developed in NDRG2-deficient mice. Therefore, this study opens the way to resolve multistep leukemogenesis of ATL and may lead to the development of novel methods of molecular diagnosis and strategies of effective molecular-targeted therapies.

Research Products

• [Journal Article] Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma (2012)
  • Author(s): Nakahata S, Saito Y, Marutsuka K, Hidaka T, Maeda K, Hatakeyama K, Shiraga T, Goto A, Takamatsu N, Asada Y, Utsunomiya A, Okayama A, Kubuki Y, Shimoda K, Ukai Y, Kurosawa G, Morishita K
  • Journal Title: Leukemia
  • DOI: doi:10.1038/leu.2011.379
  • Peer Reviewed
• [Journal Article] The Increased Expression of Integrinα6(ITGA6) Enhances Drug Resistance in EVI1 Leukemia (2012)
  • Author(s): Yamakawa N, Kaneda K, Saito Y, Ichihara E, Morishita K
  • Journal Title: PLoS One Volume: 7(1) Pages: e30706
  • DOI: doi:10.1371/journal.pone.0030706
  • Peer Reviewed
• [Journal Article] Establishment of a novel human myeloid leukemia cell line, AMU-AML1, carrying t(12 ; 22)(p13 ; q11) without chimeric MN1-TEL and with high expression of MN1 (2012)
  • Author(s): Gotou M, Hanamura I, Nagoshi H, Wakabayashi M, Sakamoto N, Tsunekawa N, Horio T, Goto M, Mizuno S, Takahashi M, Suganuma K, Yamamoto H, Hiramatsu A, Watarai M, Shikami M, Imamura A, Mihara H, Taki T, Taniwaki M, Nitta M
  • Journal Title: Genes Chromosomes Cancer Volume: 51 Pages: 42-53
  • DOI: doi:10.1002/gcc.20929
  • Peer Reviewed
• [Journal Article] Retrospective analysis of prognostic factors for angioimmunoblastic T-cell lymphoma : a multicenter cooperative study in Japan. Blood (2012)
  • Author(s): Tokunaga T, Shimada K, Yamamoto K, Chihara D, Ichihashi T, Oshima R, Tanimoto M, Iwasaki T, Isoda A, Sakai A, Kobayashi H, Kitamura K, Matsue K, Taniwaki M, Tamashima S, Saburi Y, Masunari T, Naoe T, Nakamura S, Kinoshita T
  • Journal Title: Epub ahead of print
  • DOI: doi:10.1182/blood-2011-08-374371
  • Peer Reviewed
• [Journal Article] Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers (2011)
  • Author(s): Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, and Okayama A
  • Journal Title: Int J Cancer Volume: 128 Pages: 1335-43
  • DOI: doi:10.1002/ijc.25450
  • Peer Reviewed
• [Journal Article] CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression (2011)
  • Author(s): Saito Y, Nakahata S, Yamakawa N, Kaneda K, Ichihara A, Suekane A, and Morishita K
  • Journal Title: Leukemia Volume: 25 Pages: 921-931
  • DOI: doi:10.1038/leu.2011.36
  • Peer Reviewed
• [Journal Article] Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation (2011)
  • Author(s): Nishikata I, Nakahata S, Saito Y, Kaneda K, Ichihara E, Yamakawa N, and Morishita K
  • Journal Title: Oncogene Volume: 30 Pages: 196-207
  • DOI: doi:10.1038/onc.2011.132
  • Peer Reviewed
• [Journal Article] Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1 high leukemia cells (2011)
  • Author(s): Ichihara E, Kaneda K, Saito Y, Yamakawa N, Morishita K
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 416 Pages: 239-45
  • URL: http://dx.doi.org/10.1016/j.bbrc.2011.10.061
  • Peer Reviewed
• [Journal Article] Galectin-3(Gal-3) induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia (2011)
  • Author(s): Yamamoto-Sugitani M, Kuroda J, Ashihara E, Nagoshi H, Kobayashi T, Matsumoto Y, Sasaki N, Shimura Y, Kiyota M, Nakayama R, Akaji K, Taki T, Uoshima N, Kobayashi Y, Horiike S, Maekawa T, Taniwaki M
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Pages: 17468-17473
  • DOI: doi:10.1073/pnas.1111138108
  • Peer Reviewed
• [Journal Article] Phase II/III study of R-CHOP-21 versus R-CHOP-14 for untreated indolent B-cell non-Hodgkin's lymphoma : JCOG 0203 trial (2011)
  • Author(s): Watanabe T, Tobinai K, Shibata T, Tsukasaki K, Morishima Y, Maseki N, Kinoshita T, Suzuki T, Yamaguchi M, Ando K, Ogura M, Taniwaki M, Uike N, Takeuchi K, Nawano S, Terauchi T, Hotta T
  • Journal Title: J Clin Oncol Volume: 29 Pages: 3990-3998
  • DOI: doi:10.1200/JCO.2011.34.8508
  • Peer Reviewed
• [Journal Article] Cytotoxic molecule-positive classical Hodgkin's lymphoma : a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type (2011)
  • Author(s): Asano N, Kinoshita T, Tamaru J, Ohshima K, Yoshino T, Niitsu N, Tsukamoto N, Hirabayashi K, Izutsu K, Taniwaki M, Morishima Y, Nakamura S
  • Journal Title: Haematologica Volume: 96 Pages: 1636-1643
  • DOI: doi:10.3324/haematol.2011.041079
  • Peer Reviewed
• [Journal Article] Expression of master regulators of helper T-cell differentiation in peripheral T-cell lymphoma, not otherwise specified, by immunohistochemical analysis (2010)
  • Author(s): Matsumoto Y, Horiike S, Ohshiro M, Yamamoto M, Sasaki N, Tsutsumi Y, Kobayashi T, Shimizu D, Uchiyama H, Kuroda J, Nomura K, Shimazaki C, Taniwaki M
  • Journal Title: Am J Clin Pathol Volume: 133 Pages: 281-290
  • DOI: doi:10.1309/AJCP0SBHYVLY5EML
  • Peer Reviewed
• [Journal Article] Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways (2010)
  • Author(s): Kobayashi T, Kuroda J, Ashihara E, Oomizu S, Terui Y, Taniyama A, Adachi S, Takagi T, Yamamoto M, Sasaki N, Horiike S, Hatake K, Yamauchi A, Hirashima M, Taniwaki M
  • Journal Title: Leukemia Volume: 24 Pages: 843-850
  • DOI: doi:10.1038/leu.2010.25
  • Peer Reviewed
• [Journal Article] Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2 (2010)
  • Author(s): Shimahara A, Yamakawa N, Nishikata I, Morishita K
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 16967-16977
  • DOI: doi:10.1074/jbc.M110.102046
  • Peer Reviewed
• [Journal Article] Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-β1-mediated growth suppression in adult T-cell leukemia/lymphoma (2010)
  • Author(s): Nakahata, S., Yamazaki, H., Nakauchi, H., Morishita, K
  • Journal Title: Oncogene Volume: 29 Pages: 4157-4159
  • DOI: doi:10.1038/onc.2010.172
  • Peer Reviewed
• [Journal Article] Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus 1-infected cell lines (2010)
  • Author(s): Watanabe, M., Nakahata, S., Hamasaki, M., Saito, Y., Kawano, Y., Hidaka, T., Yamashita, K., Umeki, K., Taki, T., Taniwaki, M., Okayama, A., Morishita, K
  • Journal Title: J. Virol Volume: 84 Pages: 6966-6977
  • DOI: doi:10.1128/JVI.00073-10
  • Peer Reviewed
• [Journal Article] NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. (2010)
  • Author(s): Furuta, H., Kondo, Y., Nakahata, S., Hamasaki, M., Sakoda, S., Morishita, K
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 391 Pages: 1785-1791
  • URL: http://dx.doi.org/10.1016/j.bbrc.2009.12.156
  • Peer Reviewed
• [Journal Article] Genistein Induced Apoptotic Cell Death in Adult T-Cell Leukemia Cells through Estrogen Receptors (2010)
  • Author(s): Yamasaki M, Mukai A, Ohba M, Mine Y, Sakakibara Y, Suiko M, Morishita K, Nishiyama K
  • Journal Title: Biosci Biotechnol Biochem Volume: 74 Pages: 2113-5
  • URL: http://dx.doi.org/10.1271/bbb.100359
  • Peer Reviewed
• [Journal Article] Multiple integrations of human T-lymphotropic virus type 1 proviruses in the engrafted cells from the asymptomatic carriers in NOD/SCID/gammacnull mice (2010)
  • Author(s): Yamamoto I, Takajo I, Umeki K, Morishita K, Hatakeyama K, Kataoka H, Nomura H, Okayama A
  • Journal Title: Intervirology Volume: 53 Pages: 229-39
  • DOI: doi:10.1159/000302760
  • Peer Reviewed
• [Journal Article] Involvement of LKB1 in epithelial-mesenchymal transition(EMT) of human lung cancer cells (2010)
  • Author(s): Roy BC, Kohno T, Iwakawa R, Moriguchi T, Kiyono T, Morishita K, Sanchez-Cespedes M, Akiyama T, Yokota J
  • Journal Title: Lung Cancer Volume: 70 Pages: 136-4
  • URL: http://dx.doi.org/10.1016/j.lungcan.2010.02.004
  • Peer Reviewed
• [Journal Article] SKI and MEL1 cooperate to inhibit transforming growth factor-βsignal in gastric cancer cells (2009)
  • Author(s): Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka, K, Morishita K, Yuki K., Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T
  • Journal Title: J Biol. Chem Volume: 285 Pages: 3334-3344
  • DOI: doi:10.1074/jbc.M808989200
  • Peer Reviewed
• [Journal Article] Alteration of enhancer of polycomb 1 at 10p11. 2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma (2009)
  • Author(s): Nakahata, S., Saito, Y., Hamasaki, M., Hidaka, T., Arai, Y., Taki, T., Taniwaki, M., Morishita, K
  • Journal Title: Genes, Chromosomes & Cancer Volume: 48 Pages: 768-776
  • DOI: DOI:10.1002/gcc.20681
  • Peer Reviewed
• [Presentation] 癌抑制遺伝子NDRG2の炎症反応制御機構 (2011)
  • Author(s): 市川朝永、中畑新吾、近藤雄大、長井健太郎、迫田隅男、森下和広
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-10-30
• [Presentation] 成人T細胞白血病におけるがん抑制遺伝子候補NDRG2の同定 (2011)
  • Author(s): 中畑新吾、市川朝永、齋藤祐介、新井康仁、滝智彦、谷脇雅史、森下和広
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-10-03
• [Presentation] T細胞特異的TSLC1 TgマウスはATL様病態を示す (2011)
  • Author(s): 市川朝永、中畑新吾、山口良二、西片一朗、森下和広
  • Organizer: 第4回HTLV-1研究会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2011-09-19
• [Presentation] 腫瘍溶解性ウイルスVSVを用いたATLにたいするTSLC1分子標的療法の開発 (2011)
  • Author(s): 大隈和、舘山誠司、森下和広、広瀬国孝、山本直樹、山口一成、浜口功
  • Organizer: 第4回HTLV-1研究会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2011-09-19
• [Presentation] NDRG2は成人T細胞白血病リンパ腫においてがん抑制遺伝子として働く (2011)
  • Author(s): 中畑新吾、市川朝永、齋藤祐介、新井康仁、滝智彦、谷脇雅史、森下和広
  • Organizer: 第4回HTLV-1研究会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2011-09-19
• [Presentation] Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma Leukemia the 15th International Conference on Human Retrovirology (2011)
  • Author(s): Morishita K
  • Organizer: HTLV and Related Retroviruses
  • Place of Presentation: Belgium(Leuven)
  • Year and Date: 2011-06-08
• [Presentation] 可食農水産物由来NF-κB制御化合物(EPNRE)の抗Tax・抗ATL細胞活性 (2010)
  • Author(s): 伊波英克, Mireguli Yasen, 池辺詠美, 石田由布子, 和田浩二, 田中淳一, 田中勇悦, 甲斐久博, 西園晃, 森下和広
  • Organizer: 第33回日本分子生物学会年会/第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-09
• [Presentation] Promoter methylation and down-regulation of ZEB1 are associated with low expression of CDKN1A in ATL cells (2010)
  • Author(s): Nakahata, S., Watanabe, M., Saito, Y., Morishita, K
  • Organizer: 第33回日本分子生物学会年会/第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-09
• [Presentation] CADM1特異抗体を用いたATLL(成人T細胞白血病・リンパ腫)診断・治療法の開発 (2010)
  • Author(s): 眞鍋香澄, 高松尚文, 丸塚浩助, 日高智徳, 中畑新吾, 前田宏一, 齋藤祐介, 濱崎誠, 一ノ瀬孝子, 岩田喬子, 畠山金太, 鵜飼由範, 岡山昭彦, 黒沢仁, 浅田祐士郎, 宇都宮與, 森下和広
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-09-25
• [Presentation] 成人T細胞白血病におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1発現低下により抑制される (2010)
  • Author(s): 中畑新吾, 渡邊正明, 濱崎誠, 齋藤祐介, 河野洋平, 森下和広
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-09-25
• [Presentation] Promoter methylation and down-regulation of ZEB1 are associated with low expression of CDKNIA in ATL-cells (2010)
  • Author(s): Nakahata, S., Watanabe, M., Saito, Y., Morishita, K
  • Organizer: 69th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-23
• [Presentation] ATL細胞におけるCDKN1A遺伝子の転写はプロモーターのメチル化とZEB1発現低下により抑制される (2010)
  • Author(s): 渡邊正明, 中畑新吾, 齋藤祐介, 森下和広
  • Organizer: 第3回HTLV-1研究会・合同班会議
  • Place of Presentation: 東京都港区
  • Year and Date: 2010-08-29
• [Presentation] ヒトCRTAMを発現する組換えウイルスVSVのHTLV-1感染細胞及びATL細胞に対する殺傷効果 (2010)
  • Author(s): 大隈和, 深川耕次, 高馬卓也, 森下和広, 高浜洋一, 山本直樹, 山口一成, 浜口功
  • Organizer: 第3回HTLV-1研究会・合同班会議
  • Place of Presentation: 東京都港区
  • Year and Date: 2010-08-29
• [Presentation] HAM患者PBMCにおけるTSLC-1発現の解析 (2010)
  • Author(s): 竹之内徳博, 恩額日楽, 手塚健太, 森下和広, 鵜飼由範, 黒澤仁, 中川正法, 日下博文, 藤澤順一
  • Organizer: 第3回HTLV-1研究会・合同班会議
  • Place of Presentation: 東京都港区
  • Year and Date: 2010-08-29
• [Presentation] Comprehensive isolation and characterize of anti-cancer Abs, using the human phage-Abs display system (2009)
  • Author(s): Kurosawa, G., Sumitomo, M., Muramatsu, C., Ogawa, K., Hashiba, M., Sugiura, M., Akahori, Y., Manabe, K., Ukai, Y., Morishita, K., and Kurosawa, Y
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-12-12
• [Presentation] ITGA6/ITGB4 dependent-cell adhesion ability in EIV1(+) leukemia (2009)
  • Author(s): Yamakawa, N., Saito, Y., and Morishita, K
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-12-09
• [Presentation] 成人T細胞白血病・リンパ腫(ATLL)のTSLC1/IgSF4による診断応用 (2009)
  • Author(s): 眞鍋香澄, 高松尚文, 日高智徳, 中畑新吾, 前田宏一, 濱崎誠, 岩田喬子, 鵜飼由範, 岡山昭彦, 坪内博仁, 黒沢仁, 宇都宮與, 森下和広
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2009-10-24
• [Presentation] 成人T細胞白血病リンパ腫(ATLL)におけるZEB1/TCF8転写抑制はCCNG2及びCDKN1Aの転写抑制をもたらす (2009)
  • Author(s): 中畑新吾, 浜崎誠, 渡邊正明, 森下和広
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2009-10-24
• [Presentation] Diagnostic application using TSLC1/IgSF4 antibodies to Adult T cell leukemia/lymphoma(ATLL) (2009)
  • Author(s): Manabe, K., Takamatsu, N., Hidaka, T., Nakahata, S., Naeda, K., Hamasaki, M., Iwata, T., Ukai, Y., Okayama, A., Horiuchi, H., Kurosawa, G., Utsunomiya, A., and Morishita, K
  • Organizer: 68th Annual Meeting of the JapaneseCancer Association
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-02
• [Presentation] Down-regulation of CDKN1A transcription by ZEB1/TCF8 inactivation in adult T-cell leukemia (2009)
  • Author(s): Nakahata, S., Hamasaki, M., Watanabe, M., and Morishita, K
  • Organizer: 68th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-01
• [Presentation] NDRG2 is a candidate tumor suppressor gene in adult-T cell leukemia (2009)
  • Author(s): Hamasaki, M., Nakahata, S., Saito, Y., Kawano, Y, Arai, Y, Taki, T., Taniwaki, M., and Morishita, K
  • Organizer: 68th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-01
• [Presentation] Identification and characterlization of tumor suppressor genes in ATL by chromosomal and genetic analyses (2009)
  • Author(s): Morishita, K., Taniwaki, M., and Nakahata, S
  • Organizer: 68th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-01
• [Presentation] Evi1による細胞接着機構 (2009)
  • Author(s): 山川哲生, 齋藤祐介, 森下和広
  • Organizer: 日本分子生物学会第9回春季シンポジウム
  • Place of Presentation: 宮崎市
  • Year and Date: 2009-05-11
• [Presentation] 急性骨髄性白血病の原因遺伝子EVI 1によるGATA-2転写活性化の機能解析 (2009)
  • Author(s): 島原明子, 山川哲生, 齋藤祐介, 西片一朗, 森下和広
  • Organizer: 日本分子生物学会第9回春季シンポジウム
  • Place of Presentation: 宮崎市
  • Year and Date: 2009-05-11
• [Presentation] TCF8はSmad7を抑制しATLのTGF-betal不能性を解除する (2009)
  • Author(s): 中畑新吾, 濱崎誠, 齋藤祐介, 森下和広
  • Organizer: 日本分子生物学会第9回春季シンポジウム
  • Place of Presentation: 宮崎市
  • Year and Date: 2009-05-11
• [Presentation] 口腔扁平上皮癌におけるNDRG2遺伝子の発現とその制御機構の解析 (2009)
  • Author(s): 古田浩史, 近藤雄大, 濱崎誠, 中畑新吾, 迫田隅男, 森下和広
  • Organizer: 日本分子生物学会第9回春季シンポジウム
  • Place of Presentation: 宮崎市
  • Year and Date: 2009-05-11
• [Presentation] Human phage antibody libraryを用いた癌細胞表面キャラクターの解析 (2009)
  • Author(s): 黒澤仁, 住友万里子, 村松千徳, 小川恵子, 田中美帆, 北村由香, 杉浦元孝, 高崎昭彦, 林宣宏, 赤堀泰, 高松尚文, 森下和広, 鵜飼由範, 黒澤良和
  • Organizer: 日本分子生物学会第9回春季シンポジウム
  • Place of Presentation: 宮崎市
  • Year and Date: 2009-05-11
• [Patent(Industrial Property Rights)] Tリンパ性白血病の検出方法及び検出用キット (2011)
  • Inventor(s): 森下和広、坪内博仁、谷脇雅史
  • Industrial Property Rights Holder: JST、宮崎大学
  • Industrial Property Number: 特許、特許第4794213号
  • Acquisition Date: 2011-08-05
• [Patent(Industrial Property Rights)] ヒトT細胞白血病ウイルス感染あるいは成人T細胞白血病発症の検出法、その診断薬、ならびにその予防および治療の為の薬剤 (2011)
  • Inventor(s): 森下和広,谷脇雅史、濱崎誠
  • Industrial Property Rights Holder: 宮崎大学、宮崎県産業支援財団
  • Industrial Property Number: 特許、特許第4751407号
  • Acquisition Date: 2011-05-27
• [Patent(Industrial Property Rights)] PTENのリン酸化抑制剤又は脱リン酸化剤 (2010)
  • Inventor(s): 森下和広、中畑新吾、濱崎誠
  • Industrial Property Rights Holder: 宮崎大学、宮崎県産業支援財団
  • Industrial Property Number: 特許、PCT/JP2010/055378(WO2010/116899)
  • Filing Date: 2010-03-26
  • Overseas
• [Patent(Industrial Property Rights)] 成人T細胞白血病の診断器具 (2010)
  • Inventor(s): 森下和広,小林行治
  • Industrial Property Rights Holder: みやざきTLO→宮崎県産業支援財団、アドテック
  • Industrial Property Number: 特許、特許第4536588号
  • Acquisition Date: 2010-06-25