2012 Fiscal Year Final Research Report
Analysis of the alteration of signal pathway in soft tissue sarcoma
| Project/Area Number |
21390107
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
ODA Yoshinao 九州大学, 大学院・医学研究院・形態機能病理, 教授 (70291515)
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| Co-Investigator(Kenkyū-buntansha) |
TAMIYA Sadafumi 九州大学, 大学院・医学研究院, 准教授 (60284486)
KOHASHI Kenichi 九州大学, 大学院・医学研究院, 助教 (10529879)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 骨・関節・筋肉・皮膚・感覚器 / 悪性軟部腫瘍 / Akt-mTOR pathway |
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| Research Abstract |
We demonstrated the activation of Akt-mTOR pathway in leiomyosarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, myxofibrosarcoma, solitary fibrous tumor and dermatofibrosarcoma protuberans. Activation of this pathway was correlated with histopathological malignancy and poor prognosis in these tumors. Therefore, Akt-mTOR pathway may be the candidate of molecular target in these non-small round cell sarcomas
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[Journal Article] Clinicopathologic and prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors2013
Author(s)
Endo M, Yamamoto H, Setsu N, Kohashi K, Takahashi Y, Ishii T, Hakozaki M, Aoki M, Iwasaki H, Dobashi Y, Nishiyama K, Iida K, Matsumoto Y, Iwamoto Y, Oda Y
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Journal Title
Clin Cancer Res
Volume: 19(2)
Pages: 450-461
DOI
Peer Reviewed
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[Presentation] Clinicopathological and prognostic significance of Akt-mTOR and MAPK pathways and antitumor effect of mTOR Inhibitor in malignant peripheral nerve sheath tumor2012
Author(s)
Endo M, Setsu N, Takahashi Y, Ishii T, Kohashi K, Yamamoto H, Tamiya S, Matsuda S, Iwamoto Y, Hakozaki M, Iwasaki H, Oda Y
Organizer
101^<st> USCAP Annual Meeting
Place of Presentation
Vancouver, BC, Canada
Year and Date
20120317-23
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