Abnormal NKG2D ligand expression and disease

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390112
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Hokkaido University
• Principal Investigator: KASAHARA Masanori 北海道大学, 大学院・医学研究科, 教授 (30241318)
• Co-Investigator(Kenkyū-buntansha): FUGO Kazunori 北海道大学, 大学院・医学研究科, 助教 (20431306) ; OTSUKA Noriyuki 北海道大学, 大学院・医学研究科, 助教 (00447046)
• Project Period (FY): 2009 – 2011
• Keywords: NKG2D / ナチュラルキラー細胞 / 活性化リガンド

Research Abstract

NKG2D ligands are major histocompatibility complex class I-like molecules whose expression is induced by cellular stresses such as transformation and viral infections. They function as danger signals alerting the immune system to the presence of unhealthy, stressed cells. In the present study, we analyzed the structure and function of NKG2D ligands, and their role in pathologic processes, with emphasis on the analysis of H60c, a mouse NKG2D ligand identified in our laboratory.

Research Products

• [Journal Article] 脊椎動物における抗原受容体の選択-相同リンパ球に発現される由来の異なる受容体 (2012)
  • Author(s): 須藤洋一, 笠原正典
  • Journal Title: 化学と生物 Volume: (印刷中)
• [Journal Article] Proteasome subunit β5t expression in cervical ectopic thymoma (2012)
  • Author(s): Tomaru, U., Yamada, Y., Ishizu, A., Kuroda, T., Matsuno, Y. and Kasahara, M
  • Journal Title: J. Clin. Pathol.
  • DOI: DOI:10.1136/jclinpath-2012-200820
  • Peer Reviewed
• [Journal Article] Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair (2012)
  • Author(s): Yoshida, S., Mohamed, R. H., Kajikawa, M., Koizumi, J., Tanaka, M., Fugo, K., Otsuka, N., Maenaka, K., Yagita, H., Chiba, H. and Kasahara, M.
  • Journal Title: J. Immunol Volume: 188 Pages: 3972-3979
  • Peer Reviewed
• [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities (2012)
  • Author(s): Tomaru, U., Takahashi, S., Ishizu, A., Miyatake, Y., Gohda, A., Suzuki, S., Ono, A., Ohara, J., Baba, T., Murata, S., Tanaka, K. and Kasahara, M
  • Journal Title: Am. J. Pathol Volume: 180 Pages: 963-972
  • Peer Reviewed
• [Journal Article] VLR-based adaptive immunity (2012)
  • Author(s): Boehm, T., McCurley, N., Sutoh, Y., Schorpp, M., Kasahara, M. and Cooper, M. D.
  • Journal Title: Annu. Rev. Immunol. Volume: 30 Pages: 203-220
• [Journal Article] Comparative genomic analysis of the proteasome β5t subunit gene : implications for the origin and evolution of thymoproteasomes (2012)
  • Author(s): Sutoh, Y., Kondo, M., Ohta, Y., Ota, T., Tomaru, U., Flajnik, M. F. and Kasahara, M.
  • Journal Title: Immunogenetics Volume: 64 Pages: 49-58
  • Peer Reviewed
• [Journal Article] Immune system : evolutionary pressure of infectious agents (2011)
  • Author(s): Kasahara, M.
  • Journal Title: In : D. N. Cooper and H. Kehrer-Sawatzki (eds.) : Encyclopedia of Life Sciences, John Wiley & Sons, Chichester, UK
  • DOI: DOI:10.1002/9780470015902.a0001131.pub2
  • Peer Reviewed
• [Journal Article] Expression of proteasome subunit 5t in thymic epithelial tumors (2011)
  • Author(s): Yamada, Y., Tomaru, U., Ishizu, A., Kiuchi, T., Marukawa, K., Matsuno, Y. and Kasahara, M.
  • Journal Title: Am. J. Surg. Pathol Volume: 35 Pages: 1296-1304
  • Peer Reviewed
• [Journal Article] Serum-dependent, antibody and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes (2011)
  • Author(s): Iwasaki, S., Masuda, S., Baba, T., Tomaru, U., Katsumata, K., Kasahara, M. and Ishizu, A.
  • Journal Title: Cytometry Volume: 79A Pages: 46-56
  • Peer Reviewed
• [Journal Article] 病原体認識戦略の進化 (2010)
  • Author(s): 笠松純, 瀬谷司, 笠原正典
  • Journal Title: 臨床免疫・アレルギー科 Volume: 54 Pages: 113-121
• [Journal Article] Phylogenetic and expression analysis of lamprey Toll-like receptors (2010)
  • Author(s): Kasamatsu, J., Oshiumi, H., Matsumoto, M., Kasahara, M. and Seya, T.
  • Journal Title: Dev. Comp. Immunol. Volume: 34 Pages: 855-865
  • Peer Reviewed
• [Journal Article] Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution (2010)
  • Author(s): Kondo, M., Maruoka, T., Otsuka, N., Kasamatsu, J., Fugo, K., Hanzawa, N. and Kasahara, M.
  • Journal Title: Immunogenetics Volume: 62 Pages: 441-450
  • Peer Reviewed
• [Journal Article] Identification of a third variable lymphocyte receptor in the lamprey (2010)
  • Author(s): Kasamatsu, J., Sutoh, Y., Fugo, K., Otsuka, N., Iwabuchi, K. and Kasahara, M.
  • Journal Title: Proc. Natl. Acad.Sci. USA Volume: 107 Pages: 14304-14308
  • Peer Reviewed
• [Journal Article] A novel type of E3-ligase for the Ufm1-conjugation system (2010)
  • Author(s): Tatsumi, K., Sou, Y.-S., Tada, N., Nakamura, E., Iemura, S., Natsume, T., Kang, S. H., Chung, C. H., Kasahara, M., Kominami, E., Yamamoto, M., Tanaka, K. and Komatsu, M.
  • Journal Title: J. Biol. Chem. Volume: 285 Pages: 5417-5427
  • Peer Reviewed
• [Journal Article] Originand evolution of the adaptive immune system : genetic events and selective pressures (2010)
  • Author(s): Flajnik, M. F. and Kasahara, M.
  • Journal Title: Nat. Rev. Genet. Volume: 11 Pages: 47-59
  • Peer Reviewed
• [Journal Article] 非古典的MHCクラスI分子の構造と機能 (2009)
  • Author(s): 梶川瑞穂, 笠原正典
  • Journal Title: 生化学 Volume: 81 Pages: 189-199
• [Journal Article] Human endogenous retrovirus-R env glycoprotein as autoantigen in autoimmune disease (2009)
  • Author(s): Sasaki, N., Ogawa, Y., Tomaru, U., Katsumata, K., Tanaka, S., Otsuka, N., Kasahara, M., Yoshiki, T. and Ishizu, A.
  • Journal Title: AIDS Res. Hum. Retroviruses Volume: 25 Pages: 889-896
  • Peer Reviewed
• [Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex (2009)
  • Author(s): Tomaru, U, Ishizu, A., Murata, S., Miyatake, Y., Suzuki, S., Takahashi, S., Kazamaki, T., Ohara, J., Baba, T., Iwasaki, S., Fugo, K., Otsuka, N., Tanaka, K. and Kasahara, M.
  • Journal Title: Blood Volume: 113 Pages: 5186-5191
  • Peer Reviewed
• [Presentation] ヒト癌組織におけるNKG2Dリガンドの発現 (2011)
  • Author(s): 藤田裕美,畑中豊,大塚紀幸,須藤洋一,久保田加奈子,三橋智子,笠原正典,松野吉宏
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 愛知芸術文化センター,名古屋
  • Year and Date: 20111003-05
• [Presentation] NKG2Dリガンドの創傷治癒における役割の解析 (2011)
  • Author(s): 笠原正典,Rania Mohamed,小泉潤,富居一範,大塚紀幸,吉田繁
  • Organizer: 第20回日本組織適合性学会大会
  • Place of Presentation: ツインメッセ静岡,静岡
  • Year and Date: 20110828-30
• [Presentation] 非古典的MHCクラスI分子の多様な機能 (2011)
  • Author(s): 笠原正典
  • Organizer: 第20回日本組織適合性学会大会
  • Place of Presentation: ツインメッセ静岡,静岡
  • Year and Date: 20110828-30
• [Presentation] 胸腺プロテアソームの系統発生 (2011)
  • Author(s): 笠原正典,須藤洋一,外丸詩野
  • Organizer: 第23回日本比較免疫学会
  • Place of Presentation: 海洋研究開発機構横浜研究所,横浜
  • Year and Date: 20110821-23
• [Presentation] Structure and function of variable lymphocyte receptors : an update. Symposium Evolution and Diversity of Innate and Adaptive Immune Systems (2011)
  • Author(s): Kasahara, M., Sutoh, Y. and Kasamatsu, J.
  • Organizer: International Congress of Comparative Physiology and Biochemistry
  • Place of Presentation: Nagoya Congress Center,Nagoya, Japan
  • Year and Date: 20110531-0605
• [Presentation] Characterization of adaptive immune receptors in hagfish. (2011)
  • Author(s): Guo, P., Gartland, L. A., Li, J., Alder, M. N., Herrin, B. R., Sides, J. D., Kasahara, M. and Cooper, M. D.
  • Organizer: American Association of Immunologists Meeting
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 20110513-17
• [Presentation] ヒトNKG2Dリガンドの組織発現に関する免疫組織化学検討 (2011)
  • Author(s): 藤田裕美,須藤洋一,畑中豊,富居一範,大塚紀幸,松野吉宏,笠原正典
  • Organizer: 第100回日本病理学会
  • Place of Presentation: パシフィコ横浜,横浜
  • Year and Date: 20110428-30
• [Presentation] 体表組織におけるナチュラルキラー細胞活性化リガンドH60cの役割 (2011)
  • Author(s): 吉田繁,小泉潤,富居一範,近藤瑞穂,大塚紀幸,笠原正典
  • Organizer: 第100回日本病理学会
  • Place of Presentation: パシフィコ横浜,横浜
  • Year and Date: 20110428-30
• [Presentation] 母児間免疫寛容に関わるNKG2Dリガンド発現の解析 (2011)
  • Author(s): 大塚紀幸,近藤瑞穂,吉田繁,笠原正典
  • Organizer: 第100回日本病理学会
  • Place of Presentation: パシフィコ横浜,横浜
  • Year and Date: 20110428-30
• [Presentation] Blockade of interactions between NKG2D and an NKG2D ligand H60c delays wound healing (2011)
  • Author(s): Rania Mohamed,吉田繁,小泉潤,富居一範,大塚紀幸,笠原正典
  • Organizer: 第44回北海道病理談話会
  • Place of Presentation: 旭川市国際会議場,旭川
  • Year and Date: 2011-09-10
• [Presentation] H60c is a specialized NKG2D ligand with a major role in immune surveillance at the body surface (2010)
  • Author(s): Yoshida, S., Fugo, K., Kajikawa, M., Kondo, M., Otsuka, N., Maenaka, K. and Kasahara, M.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe Convention Center, Kobe, Japan
  • Year and Date: 20100823-27
• [Presentation] Skewed T cell development in mice with ectopic expression of thymoproteasome (2010)
  • Author(s): Tomaru, U., Suzuki, S., Ishizu, A., Takahashi, S., Ohara, J., Miyatake, Y., Murata, S., Tanaka, K. and Kasahara, M.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe Convention Center, Kobe, Japan
  • Year and Date: 20100823-27
• [Presentation] Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution (2010)
  • Author(s): Kondo, M., Maruoka, T., Otsuka, N., Kasamatsu, J., Fugo, K., Hanzawa, N., and Kasahara, M.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe Convention Center,Kobe, Japan
  • Year and Date: 20100823-27
• [Presentation] 近交系マウスにおけるNKG2Dリガンド遺伝子のコピー数多型 (2010)
  • Author(s): 富居一範,皿田雄二,笠松純,近藤瑞穂,吉田繁,須藤洋一,大塚紀幸,笠原正典
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル,東京
  • Year and Date: 20100427-29
• [Presentation] 粘膜免疫におけるナチュラルキラー細胞活性化リガンドH60cの役割 (2010)
  • Author(s): 吉田繁,富居一範,近藤瑞穂,大塚紀幸,笠原正典
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル,東京
  • Year and Date: 20100427-29
• [Presentation] Characterization of variable lymphocyte receptors in hagfish (2010)
  • Author(s): Guo, P., Gartland, L. A., Alder, M. N, Herrin, B. R., Kasahara, M. and Cooper, M. D.
  • Organizer: Keystone symposia Lymphocyte Activation and Gene Expression
  • Place of Presentation: Breckenridge, Colorado, USA
  • Year and Date: 20100227-0304
• [Presentation] 皮膚における免疫監視に重要なNKG2DリガンドH60cの解析 (2010)
  • Author(s): 小泉潤,吉田繁,梶川瑞穂,近藤瑞穂,富居一範,大塚紀幸,前仲勝実,笠原正典
  • Organizer: 第99回北海道癌談話会例会
  • Place of Presentation: 北海道大学医学部臨床第3講堂,札幌
  • Year and Date: 2010-10-23
• [Presentation] 哺乳類におけるNKG2D ligand領域の比較ゲノム解析 (2009)
  • Author(s): 近藤瑞穂,丸岡尊子,笠松純,大塚紀幸,吉田繁,富居一範,半澤直人,笠原正典
  • Organizer: 第11回日本進化学会大会
  • Place of Presentation: 北海道大学高等教育機能開発総合センター,札幌
  • Year and Date: 20090903-04
• [Presentation] 哺乳類におけるNKG2D ligand領域の比較ゲノム解析 (2009)
  • Author(s): 近藤瑞穂,丸岡尊子,笠松純,大塚紀幸,吉田繁,富居一範,半澤直人,笠原正典
  • Organizer: 第21回日本比較免疫学会学術集会
  • Place of Presentation: 日本大学生物資源科学部本館3階中講堂,藤沢
  • Year and Date: 20090803-05
• [Book] 分子進化と分子系統樹,生化学事典 (2012)
  • Author(s): 笠原正典
  • Publisher: 朝倉書店,東京(印刷中)
• [Book] 免疫システムの由来と成り立ち,現代生物科学入門,第5巻免疫・感染生物学 (2011)
  • Author(s): 笠原正典
  • Total Pages: 159-197
  • Publisher: 岩波書店,東京
• [Book] 主要組織適合遺伝子複合体,ほか18項目,生物学辞典 (2010)
  • Author(s): 笠原正典
  • Total Pages: 1-1382
  • Publisher: 東京化学同人,東京
• [Book] Genome duplication and T cell immunity, Development of T Cell Immunity, Progress in Molecular Biology and Translational Science (formerly, Progress in Nucleic Acid Research and MolecularBiology) (2010)
  • Author(s): Kasahara, M
  • Total Pages: 7-36
  • Publisher: Liston, A. (ed.), Elsevier, B.V.
• [Book] 主要組織適合遺伝子複合体,ほか15項目,医学大辞典第2版 (2009)
  • Author(s): 笠原正典
  • Publisher: 医学書院,東京
• [Book] 免疫異常,NEWエッセンシャル病理学改訂6版 (2009)
  • Author(s): 外丸詩野,笠原正典
  • Total Pages: 155-175
  • Publisher: 医歯薬出版
• [Remarks]
  • URL: http://www.path1-hokudai.jp/path1/Welcome.html